Microbleed prevalence and burden in anticoagulant-associated intracerebral bleed.
Journal
Annals of clinical and translational neurology
ISSN: 2328-9503
Titre abrégé: Ann Clin Transl Neurol
Pays: United States
ID NLM: 101623278
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
26
04
2019
revised:
21
05
2019
accepted:
06
06
2019
entrez:
13
8
2019
pubmed:
14
8
2019
medline:
30
5
2020
Statut:
ppublish
Résumé
Prior studies suggest an association between Vitamin K antagonists (VKA) and cerebral microbleeds (CMBs); less is known about nonvitamin K oral anticoagulants (NOACs). In this observational study we describe CMB profiles in a multicenter cohort of 89 anticoagulation-related intracerebral hemorrhage (ICH) patients. CMB prevalence was 51% (52% in VKA-ICH, 48% in NOAC-ICH). NOAC-ICH patients had lower median CMB count [2(IQR:1-3) vs. 7(4-11); P < 0.001]; ≥5 CMBs were less prevalent in NOAC-ICH (4% vs. 31%, P = 0.006). This inverse association between NOAC exposure and high CMB count persisted in multivariable logistic regression models adjusting for potential confounders (OR 0.10, 95%CI: 0.01-0.83; P = 0.034).
Identifiants
pubmed: 31402613
doi: 10.1002/acn3.50834
pmc: PMC6689674
doi:
Substances chimiques
Anticoagulants
0
Vitamin K
12001-79-5
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1546-1551Informations de copyright
© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.
Références
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
Neurology. 2019 Feb 19;92(8):e774-e781
pubmed: 30674594
Stroke. 2018 Oct;49(10):2309-2316
pubmed: 30355114
Neurology. 2008 Apr 1;70(14):1208-14
pubmed: 18378884
Stroke. 2011 Mar;42(3):656-61
pubmed: 21307170
Acta Neurol Scand. 2018 Aug;138(2):163-169
pubmed: 29663313
Neurology. 2017 Aug 22;89(8):820-829
pubmed: 28747441
Stroke. 2010 Jun;41(6):1222-8
pubmed: 20431083
Neurology. 2017 Dec 5;89(23):2317-2326
pubmed: 29117953
Lancet Neurol. 2018 Jun;17(6):539-547
pubmed: 29778365
Int J Stroke. 2018 Jul;13(5):454-468
pubmed: 29338604
J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1373-7
pubmed: 25847305
Stroke. 2010 Oct;41(10 Suppl):S103-6
pubmed: 20876479
J Neurol Neurosurg Psychiatry. 2018 Jul;89(7):680-686
pubmed: 29599284
Neurology. 2017 Sep 12;89(11):1142-1151
pubmed: 28814457
Stroke. 2014 Nov;45(11):3436-9
pubmed: 25316276
Lancet. 2014 Mar 15;383(9921):955-62
pubmed: 24315724