A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.
Animals
Biocompatible Materials
/ chemistry
Bone and Bones
/ metabolism
Catalysis
Cell Differentiation
Cell Survival
Collagen
/ chemistry
Culture Media
/ chemistry
Drug Combinations
Humans
Hydrogels
/ chemistry
Laminin
/ chemistry
Liver
/ metabolism
Mesenchymal Stem Cells
/ metabolism
Organoids
/ chemistry
Peptides
/ chemistry
Polyethylene Glycols
/ chemistry
Proteoglycans
/ chemistry
Swine
Tissue Engineering
/ instrumentation
Tissue Scaffolds
/ chemistry
FXIII
Matrigel
gelatin
liver organoids
osteogenesis
polyethylene glycol
vasculogenesis
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
23
07
2019
pubmed:
14
8
2019
medline:
12
9
2020
entrez:
13
8
2019
Statut:
ppublish
Résumé
For creating functional tissue analogues in tissue engineering, stem cells require very specific 3D microenvironments to thrive and mature. Demanding (stem) cell types that are used nowadays can find such an environment in a heterogeneous protein mixture with the trade name Matrigel. Several variations of synthetic hydrogel platforms composed of poly(ethylene glycol) (PEG), which are spiked with peptides, have been recently developed and shown equivalence to Matrigel for stem cell differentiation. Here a clinically relevant hydrogel platform, based on PEG and gelatin, which even outperforms Matrigel when targeting 3D prevascularized bone and liver organoid tissue engineering models is presented. The hybrid hydrogel with natural and synthetic components stimulates efficient cell differentiation, superior to Matrigel models. Furthermore, the strength of this hydrogel lies in the option to covalently incorporate unmodified proteins. These results demonstrate how a hybrid hydrogel platform with intermediate biological complexity, when compared to existing biological materials and synthetic PEG-peptide approaches, can efficiently support tissue development from human primary cells.
Identifiants
pubmed: 31402634
doi: 10.1002/adhm.201900979
pmc: PMC7116179
mid: EMS96593
doi:
Substances chimiques
Biocompatible Materials
0
Culture Media
0
Drug Combinations
0
Hydrogels
0
Laminin
0
Peptides
0
Proteoglycans
0
matrigel
119978-18-6
Polyethylene Glycols
3WJQ0SDW1A
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900979Subventions
Organisme : European Union FP7-MC-IRSES
ID : 318553
Pays : International
Organisme : New Zealand Health Research Council Emerging Researcher
ID : 15/483
Pays : International
Organisme : European Research Council
ID : #647426
Pays : International
Organisme : European Research Council
ID : 3D-JOINT
Pays : International
Organisme : European Research Council
ID : 647426
Pays : International
Informations de copyright
© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
Curr Opin Cell Biol. 2010 Oct;22(5):651-8
pubmed: 20708398
Lab Invest. 2014 Mar;94(3):340-9
pubmed: 24395110
Proteomics. 2010 May;10(9):1886-90
pubmed: 20162561
Tissue Eng Part A. 2012 Jan;18(1-2):208-18
pubmed: 21859278
Bioconjug Chem. 1999 Jan-Feb;10(1):75-81
pubmed: 9893967
Biotechnol Lett. 2004 Mar;26(6):509-15
pubmed: 15127793
Bioconjug Chem. 2001 Nov-Dec;12(6):1051-6
pubmed: 11716699
Nat Cell Biol. 2017 Nov;19(11):1326-1335
pubmed: 29058719
Biomaterials. 2016 May;87:104-117
pubmed: 26914701
Adv Drug Deliv Rev. 2012 Sep;64(12):1078-89
pubmed: 22465487
Biomacromolecules. 2012 Mar 12;13(3):604-11
pubmed: 22263670
In Vivo. 1998 Mar-Apr;12(2):183-6
pubmed: 9627800
Macromol Biosci. 2012 Mar;12(3):322-32
pubmed: 22493796
Nature. 2013 Feb 14;494(7436):247-50
pubmed: 23354049
Biomacromolecules. 2016 May 9;17(5):1553-60
pubmed: 27014785
Cell. 2015 Jan 15;160(1-2):299-312
pubmed: 25533785
J Struct Biol. 2009 Sep;167(3):216-9
pubmed: 19481153
Biomacromolecules. 2007 Oct;8(10):3000-7
pubmed: 17883273
Annu Rev Med. 2017 Jan 14;68:29-40
pubmed: 27732788
Am J Pathol. 2008 May;172(5):1441; author reply 1441-2
pubmed: 18403599
Blood. 2015 Nov 12;126(20):2329-37
pubmed: 26359437
J Biomed Mater Res A. 2018 Jan;106(1):201-209
pubmed: 28884519
Tissue Eng Part A. 2011 Sep;17(17-18):2199-212
pubmed: 21529248
Nat Cell Biol. 2016 Mar;18(3):246-54
pubmed: 26911908
J Cell Biol. 1992 Sep;118(6):1511-22
pubmed: 1522121
Nat Rev Mater. 2016;1:
pubmed: 29214058
Biomaterials. 2012 Jan;33(1):48-58
pubmed: 21955690
J Control Release. 2013 Dec 28;172(3):1075-91
pubmed: 24096021
Biomaterials. 2014 Feb;35(6):1845-56
pubmed: 24314597
Biomaterials. 2004 Aug;25(17):3915-21
pubmed: 15020168
Nat Protoc. 2017 Nov;12(11):2263-2274
pubmed: 28981121
Cold Spring Harb Perspect Biol. 2011 Dec 01;3(12):
pubmed: 21917992
Eur Cell Mater. 2018 May 30;35:335-348
pubmed: 29873804
Acta Biomater. 2013 Sep;9(9):8440-8
pubmed: 23747323
J Oral Maxillofac Res. 2012 Jan 01;2(4):e5
pubmed: 24422002
FASEB J. 1999 Dec;13(15):2214-24
pubmed: 10593869
Biomaterials. 2013 Sep;34(29):7097-105
pubmed: 23800741
Biofabrication. 2011 Jun;3(2):021001
pubmed: 21597163
Biophys J. 2011 Jan 19;100(2):284-93
pubmed: 21244824
Circulation. 2005 Mar 29;111(12):1556-66
pubmed: 15795364
Adv Funct Mater. 2012 May 23;22(10):2027-2039
pubmed: 22907987
Nat Biomed Eng. 2017;1:
pubmed: 29104816
Proc Natl Acad Sci U S A. 1989 Feb;86(3):933-7
pubmed: 2915988
J Biomed Mater Res A. 2015 Jun;103(6):2109-17
pubmed: 25294368
Ann Thorac Surg. 2000 May;69(5):1376-82
pubmed: 10881808
EMBO Rep. 2018 Aug;19(8):
pubmed: 29967223
Nat Commun. 2015 Apr 28;6:6933
pubmed: 25917746
J Vet Med Sci. 2012 Jul;74(7):827-36
pubmed: 22313966
J Oral Maxillofac Res. 2011 Oct 01;2(3):e3
pubmed: 24421995
Nat Mater. 2016 Mar;15(3):326-34
pubmed: 26618884
Semin Cancer Biol. 2005 Oct;15(5):378-86
pubmed: 15975825
Cell Stem Cell. 2016 Jan 7;18(1):25-38
pubmed: 26748754
Biomaterials. 2007 Sep;28(26):3856-66
pubmed: 17568666
Curr Protoc Cell Biol. 2012 Dec;Chapter 10:10.1.1-10.1.16
pubmed: 23208544
Int Neurourol J. 2016 May;20(Suppl 1):S23-29
pubmed: 27230457
Biofabrication. 2016 Jan 08;8(1):013001
pubmed: 26744832
Biofabrication. 2017 Mar 06;9(1):013001
pubmed: 28211365
Biomaterials. 2016 Oct;103:86-100
pubmed: 27372423
Calcif Tissue Int. 1989 Aug;45(2):74-80
pubmed: 2476206
Tissue Eng Part B Rev. 2012 Jun;18(3):155-66
pubmed: 22220809
Stem Cell Reports. 2015 Dec 8;5(6):1250-1262
pubmed: 26626180
Trends Biotechnol. 2016 Sep;34(9):733-745
pubmed: 27032730
Adv Drug Deliv Rev. 2014 Dec 15;79-80:3-18
pubmed: 24997339
Adv Healthc Mater. 2016 Feb 18;5(4):489-98
pubmed: 26693678
Tissue Eng. 2006 Sep;12(9):2685-93
pubmed: 16995802
Adv Funct Mater. 2009 Jul 24;19(14):2325
pubmed: 20148198
Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):519-27
pubmed: 20062969
J Cell Biol. 1988 Oct;107(4):1589-98
pubmed: 3049626
Nat Biotechnol. 2005 Jul;23(7):879-84
pubmed: 15965465
Lancet. 2006 Apr 15;367(9518):1241-6
pubmed: 16631879
Biofabrication. 2018 Jan 12;10(2):024103
pubmed: 29199637
Biomaterials. 2008 Dec;29(35):4658-64
pubmed: 18799212
Am J Sports Med. 2014 Jun;42(6):1384-94
pubmed: 24714783
IEEE Trans Med Imaging. 2005 Apr;24(4):549-53
pubmed: 15822812
Dev Biol. 2010 May 1;341(1):126-40
pubmed: 19854168
Nat Rev Cancer. 2003 Jun;3(6):422-33
pubmed: 12778132
Nature. 2016 Nov 24;539(7630):560-564
pubmed: 27851739
Adv Healthc Mater. 2014 Nov;3(11):1769-75
pubmed: 24833514
Tissue Eng Part A. 2011 Jul;17(13-14):1713-23
pubmed: 21306293
J Card Surg. 2003 Nov-Dec;18(6):504-6
pubmed: 14992100
Stem Cells. 2013 Jan;31(1):1-7
pubmed: 23081828