Loxapine for Treatment of Patients With Refractory, Chemotherapy-Induced Neuropathic Pain: A Prematurely Terminated Pilot Study Showing Efficacy But Limited Tolerability.

Slack channel analgesia loxapine neuropathic pain tolerability and safety

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2019
Historique:
received: 22 02 2019
accepted: 01 07 2019
entrez: 13 8 2019
pubmed: 14 8 2019
medline: 14 8 2019
Statut: epublish

Résumé

Neuropathic pain is a debilitating and commonly treatment-refractory condition requiring novel therapeutic options. Accumulating preclinical studies indicate that the potassium channel Slack (K

Identifiants

pubmed: 31402867
doi: 10.3389/fphar.2019.00838
pmc: PMC6669235
doi:

Banques de données

ClinicalTrials.gov
['NCT02820519']

Types de publication

Journal Article

Langues

eng

Pagination

838

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Auteurs

Sven Schmiedl (S)

Philipp Klee-Institute for Clinical Pharmacology, Helios University Hospital Wuppertal, Wuppertal, Germany.
Department of Clinical Pharmacology, School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.

David Peters (D)

Philipp Klee-Institute for Clinical Pharmacology, Helios University Hospital Wuppertal, Wuppertal, Germany.
Department of Clinical Pharmacology, School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Oliver Schmalz (O)

Clinic of Internal Medicine I, Division of Oncology and Palliative Care, Helios University Hospital Wuppertal, Wuppertal, Germany.

Anke Mielke (A)

Clinic for Anesthesiology, Pain Management Unit, Helios University Hospital Wuppertal, Wuppertal, Germany.

Tanja Rossmanith (T)

Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), branch for Translational Medicine and Pharmacology of the Fraunhofer IME, Frankfurt, Germany.

Shirin Diop (S)

Neurobiology and Genetics of Behavior, Department of Psychology and Psychotherapy, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Martina Piefke (M)

Neurobiology and Genetics of Behavior, Department of Psychology and Psychotherapy, Centre for Biomedical Education and Research (ZBAF), Witten/Herdecke University, Witten, Germany.

Petra Thürmann (P)

Philipp Klee-Institute for Clinical Pharmacology, Helios University Hospital Wuppertal, Wuppertal, Germany.
Department of Clinical Pharmacology, School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.

Achim Schmidtko (A)

Institute of Pharmacology and Toxicology, Centre for Biomedical Education and Research (ZBAF), School of Medicine, Faculty of Health, Witten/Herdecke University, Witten, Germany.
Institute of Pharmacology and Clinical Pharmacy, College of Pharmacy, Goethe University, Frankfurt, Germany.

Classifications MeSH