Engineering
Antineoplastic Agents
/ therapeutic use
Biosensing Techniques
/ methods
Cell Hypoxia
/ physiology
Drug Monitoring
/ methods
Enzyme Activation
Escherichia coli
/ enzymology
Escherichia coli Proteins
/ genetics
Etanidazole
/ analogs & derivatives
Genetic Therapy
/ methods
HCT116 Cells
Humans
Hydrocarbons, Fluorinated
/ chemistry
Imidazoles
/ pharmacology
Molecular Imaging
/ methods
Neoplasms
/ drug therapy
Nitroimidazoles
/ pharmacology
Nitroreductases
/ genetics
Positron-Emission Tomography
/ methods
Prodrugs
/ metabolism
Protein Engineering
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
03 09 2019
03 09 2019
Historique:
pubmed:
14
8
2019
medline:
9
6
2020
entrez:
13
8
2019
Statut:
ppublish
Résumé
Gene-directed enzyme prodrug therapy (GDEPT) uses tumor-tropic vectors to deliver prodrug-converting enzymes such as nitroreductases specifically to the tumor environment. The nitroreductase NfsB from
Identifiants
pubmed: 31403283
doi: 10.1021/acs.biochem.9b00376
doi:
Substances chimiques
Antineoplastic Agents
0
Escherichia coli Proteins
0
Hydrocarbons, Fluorinated
0
Imidazoles
0
Nitroimidazoles
0
Prodrugs
0
SN33623
0
Etanidazole
30DKA3Q1HL
2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)acetamide
383HJ2T87O
NfsB protein, E coli
EC 1.7.-
Nitroreductases
EC 1.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM