Rapid response to meningococcal disease cluster in Foya district, Lofa County, Liberia January to February 2018.
Adolescent
Aged, 80 and over
Anti-Bacterial Agents
/ administration & dosage
Child
Child, Preschool
Ciprofloxacin
/ administration & dosage
Disease Outbreaks
Female
Humans
Liberia
/ epidemiology
Male
Meningitis, Meningococcal
/ epidemiology
Meningococcal Infections
/ epidemiology
Middle Aged
Neisseria meningitidis
/ isolation & purification
Population Surveillance
Foya
Klemabendu
Lofa
Meningococcal disease
meningitis belt
rapid response
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
09
2018
accepted:
07
01
2019
entrez:
13
8
2019
pubmed:
14
8
2019
medline:
7
9
2019
Statut:
epublish
Résumé
Early detection of disease outbreaks is paramount to averting associated morbidity and mortality. In January 2018, nine cases including four deaths associated with meningococcal disease were reported in three communities of Foya district, Lofa County, Liberia. Due to the porous borders between Lofa County and communities in neighboring Sierra Leone and Guinea, the possibility of epidemic spread of meningococcal disease could not be underestimated. The county incidence management system (IMS) was activated that coordinated the response activities. Daily meetings were conducted to review response activities progress and challenges. The district rapid response team (DRRT) was the frontline responders. The case based investigation form; case line list and contacts list were used for data collection. A data base was established and analysed daily for action. Tablets Ciprofloxacin were given for chemoprophylaxis. Sixty-seven percent (67%) of the cases were males and also 67% of the affected age range was 3 to 14 years and attending primary school. The attack rate was 7/1,000 population and case fatality rate was 44.4 % with majority of the deaths occurring within 24-48 hours of symptoms onset. Three of the cases tested positive for Neisseria Meningitidis sero-type W while six cases were Epi-linked. None of the cases had recent meningococcal vaccination and no health-worker infections were registered. This cluster of cases of meningococcal disease during the meningitis season in a country that is not traditionally part of the meningitis belt emphasized the need for strengthening surveillance, preparedness and response capacity to meningitis.
Identifiants
pubmed: 31404290
doi: 10.11604/pamj.supp.2019.33.2.17095
pii: PAMJ-SUPP-33-2-06
pmc: PMC6675931
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ciprofloxacin
5E8K9I0O4U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6Subventions
Organisme : World Health Organization
ID : 001
Pays : International
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Infect Dis. 1999 Dec;180(6):1894-901
pubmed: 10558946
Arch Dis Child. 2001 Nov;85(5):386-90
pubmed: 11668100
Emerg Infect Dis. 2002 Feb;8(2):145-53
pubmed: 11897065
Lancet. 2006 Feb 4;367(9508):397-403
pubmed: 16458763
Curr Treat Options Neurol. 2010 Sep;12(5):464-74
pubmed: 20842601
Lancet Infect Dis. 2010 Dec;10(12):853-61
pubmed: 21075057
J Prev Med Hyg. 2012 Jun;53(2):116-9
pubmed: 23240173
PLoS One. 2013 Jul 19;8(7):e69783
pubmed: 23894538
Arq Neuropsiquiatr. 2013 Sep;71(9B):653-8
pubmed: 24141498
N Engl J Med. 2014 Oct 16;371(16):1481-95
pubmed: 25244186
Lancet. 2015 Jan 10;385(9963):91-2
pubmed: 25706456
Emerg Infect Dis. 2016 Oct;22(10):1827-9
pubmed: 27649257
MMWR Morb Mortal Wkly Rep. 2017 Oct 27;66(42):1140-1143
pubmed: 29072886
MMWR Morb Mortal Wkly Rep. 2017 Oct 27;66(42):1144-1147
pubmed: 29073124
PLoS One. 2017 Oct 27;12(10):e0186687
pubmed: 29077720
PLoS Curr. 2017 Nov 9;9:
pubmed: 29188127
PLoS Negl Trop Dis. 2018 Jan 5;12(1):e0006135
pubmed: 29304039
Open Forum Infect Dis. 2017 Nov 11;5(1):ofx246
pubmed: 29322063
J Clin Microbiol. 1994 Feb;32(2):323-30
pubmed: 8150942