AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.
AMP-Activated Protein Kinases
/ physiology
Active Transport, Cell Nucleus
Aminoimidazole Carboxamide
/ analogs & derivatives
Animals
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ physiology
Cells, Cultured
Gene Expression Profiling
Hepatocytes
/ metabolism
Mice
Phosphorylation
Proto-Oncogene Proteins
/ physiology
Ribonucleotides
/ pharmacology
TOR Serine-Threonine Kinases
/ physiology
Tumor Suppressor Proteins
/ physiology
Zebrafish
991
AICAR
Birt-Hogg-Dubé syndrome
folliculin
folliculin interacting protein
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
14
8
2019
medline:
29
5
2020
entrez:
13
8
2019
Statut:
ppublish
Résumé
AMPK is a central regulator of energy homeostasis. AMPK not only elicits acute metabolic responses but also promotes metabolic reprogramming and adaptations in the long-term through regulation of specific transcription factors and coactivators. We performed a whole-genome transcriptome profiling in wild-type (WT) and AMPK-deficient mouse embryonic fibroblasts (MEFs) and primary hepatocytes that had been treated with 2 distinct classes of small-molecule AMPK activators. We identified unique compound-dependent gene expression signatures and several AMPK-regulated genes, including folliculin (
Identifiants
pubmed: 31404503
doi: 10.1096/fj.201900841R
pmc: PMC6902666
doi:
Substances chimiques
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Bhd protein, mouse
0
Proto-Oncogene Proteins
0
Ribonucleotides
0
Tcfeb protein, mouse
0
Tumor Suppressor Proteins
0
Aminoimidazole Carboxamide
360-97-4
mTOR protein, mouse
EC 2.7.1.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
AICA ribonucleotide
F0X88YW0YK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12374-12391Références
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