The Abnormal CD4+T Lymphocyte Subset Distribution and Vbeta Repertoire in New-onset Rheumatoid Arthritis Can Be Modulated by Methotrexate Treament.
CD4+ T lymphocytes
TCR Vb
flow cytometry
methotrexate
rheumatoid arthritis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
10 08 2019
10 08 2019
Historique:
received:
15
06
2019
revised:
17
07
2019
accepted:
06
08
2019
entrez:
14
8
2019
pubmed:
14
8
2019
medline:
12
5
2020
Statut:
epublish
Résumé
Patients with long-term, treated, rheumatoid arthritis (RA) show abnormalities in their circulating CD4+ T-lymphocytes, but whether this occurs in recently diagnosed naïve patients to disease-modifying drugs (DMARDs) is under discussion. These patients show heterogeneous clinical response to methotrexate (MTX) treatment. We have examined the count of circulating CD4+ T-lymphocytes, and their naïve (T
Identifiants
pubmed: 31405169
pii: cells8080871
doi: 10.3390/cells8080871
pmc: PMC6721760
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Methotrexate
YL5FZ2Y5U1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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