The Benefits of Oral Rehydration on Orthostatic Intolerance in Children with Postural Tachycardia Syndrome.
Journal
The Journal of pediatrics
ISSN: 1097-6833
Titre abrégé: J Pediatr
Pays: United States
ID NLM: 0375410
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
09
04
2019
revised:
11
07
2019
accepted:
15
07
2019
pubmed:
14
8
2019
medline:
26
5
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
To evaluate whether equal volumes of oral rehydration solution (ORS) or intravenous (IV) saline provide similar improvements in cardiovascular status during controlled orthostatic challenge when administered to subjects with postural tachycardia syndrome (POTS) with orthostatic intolerance. We studied the neurovascular response to fluid loading during orthostatic stress using lower body negative pressure (LBNP) in 10 subjects with POTS with orthostatic intolerance and 15 controls, and on subsequent days before and 1 hour after IV saline infusion or ingestion of ORS. Subjects with POTS exhibited reduced tolerance to LBNP (P < .0001) compared with controls (Orthostatic Index of 35 715 ± 3469 vs 93 980 ± 7977, respectively). In POTS, following ORS but not saline infusion, cerebral blood flow velocity (CBF Maintenance of CBF
Identifiants
pubmed: 31405524
pii: S0022-3476(19)30893-5
doi: 10.1016/j.jpeds.2019.07.041
pmc: PMC6815702
mid: NIHMS1535241
pii:
doi:
Substances chimiques
Rehydration Solutions
0
Saline Solution
0
Types de publication
Clinical Trial
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
96-102Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL112736
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134674
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS094644
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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