A case control study of clinical and biochemical parameters of metabolic syndrome with special attention among young and middle aged population.
Adolescent
Adult
Aged
Anthropometry
Biomarkers
/ analysis
Cardiovascular Diseases
/ etiology
Case-Control Studies
Cerebrovascular Disorders
/ etiology
Diabetes Mellitus
/ etiology
Female
Follow-Up Studies
Humans
Lipids
/ analysis
Male
Metabolic Syndrome
/ complications
Middle Aged
Prognosis
Renal Insufficiency, Chronic
/ etiology
Young Adult
Diabetes
HbA1c
Hypertension
Metabolic syndrome
Obesity
Prevalence
Stroke
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Historique:
received:
18
06
2019
accepted:
10
07
2019
entrez:
14
8
2019
pubmed:
14
8
2019
medline:
7
1
2020
Statut:
ppublish
Résumé
Metabolic syndrome (MS) increases the risk of heart disease, stroke, and other complications. The aim of this study was to assess the clinical and biochemical parameters of MS and its complications (cerebrovascular accidents, cardiovascular accidents, DN or chronic kidney disease (CKD) compared with healthy controls especially among the younger population in Northern India. A total of 245 (healthy, MS and it's complicated) aged 18-70 years participated in the Open-Label, Single Centered; hospital-based random selection case-control comparative study. All anthropometric and biochemical assessment was done after proper consent. The metabolic syndrome was determined by IDF criteria. The key risk parameters in three groups i.e. Control, Metabolic syndrome, and Complicated was TG (96.5 ± 46.9, 194.1 ± 87.8, 148.0 ± 102.2). LDL (91.2 ± 27.2, 114.0 ± 31.8, 69.1 ± 42.5, BP (120.1 ± 9.9, 139.3 ± 13.3, 132.1 ± 15.0) and high fasting glucose (81.1 ± 13.7, 164.5 ± 84.3, 138.0 ± 74.5). The hs-CRP is also significantly increased in the complicated group. The subanalysis of data also indicates that younger middle age (36-55 years) group both male and female is obese, hypertensive, diabetic with lipid abnormality according to IDF criteria. The risk factors like high TG, low HDL, high BP, and high fasting glucose were found higher particularly in younger population which may lead to diagnosis & complications of diabetes, hypertension and lipid abnormality. Due to changing physiology in young and middle age population these individuals are moving towards metabolic syndrome easily and needs frequent monitoring, preventive checkups, and lifestyle changes to prevent complications.
Sections du résumé
BACKGROUND
BACKGROUND
Metabolic syndrome (MS) increases the risk of heart disease, stroke, and other complications.
AIM
OBJECTIVE
The aim of this study was to assess the clinical and biochemical parameters of MS and its complications (cerebrovascular accidents, cardiovascular accidents, DN or chronic kidney disease (CKD) compared with healthy controls especially among the younger population in Northern India.
MATERIAL AND METHODS
METHODS
A total of 245 (healthy, MS and it's complicated) aged 18-70 years participated in the Open-Label, Single Centered; hospital-based random selection case-control comparative study. All anthropometric and biochemical assessment was done after proper consent. The metabolic syndrome was determined by IDF criteria.
RESULTS
RESULTS
The key risk parameters in three groups i.e. Control, Metabolic syndrome, and Complicated was TG (96.5 ± 46.9, 194.1 ± 87.8, 148.0 ± 102.2). LDL (91.2 ± 27.2, 114.0 ± 31.8, 69.1 ± 42.5, BP (120.1 ± 9.9, 139.3 ± 13.3, 132.1 ± 15.0) and high fasting glucose (81.1 ± 13.7, 164.5 ± 84.3, 138.0 ± 74.5). The hs-CRP is also significantly increased in the complicated group. The subanalysis of data also indicates that younger middle age (36-55 years) group both male and female is obese, hypertensive, diabetic with lipid abnormality according to IDF criteria.
CONCLUSION
CONCLUSIONS
The risk factors like high TG, low HDL, high BP, and high fasting glucose were found higher particularly in younger population which may lead to diagnosis & complications of diabetes, hypertension and lipid abnormality. Due to changing physiology in young and middle age population these individuals are moving towards metabolic syndrome easily and needs frequent monitoring, preventive checkups, and lifestyle changes to prevent complications.
Identifiants
pubmed: 31405690
pii: S1871-4021(19)30422-9
doi: 10.1016/j.dsx.2019.07.031
pii:
doi:
Substances chimiques
Biomarkers
0
Lipids
0
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2653-2659Informations de copyright
Copyright © 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.