Neuroanatomical abnormalities related to dexamethasone exposure in survivors of childhood acute lymphoblastic leukemia.
Adolescent
Adult
Antineoplastic Agents, Hormonal
/ adverse effects
Cancer Survivors
/ statistics & numerical data
Case-Control Studies
Child
Child, Preschool
Cross-Sectional Studies
Dexamethasone
/ adverse effects
Female
Follow-Up Studies
Humans
Infant
Male
Mental Disorders
/ chemically induced
Neuroanatomy
Neuropsychological Tests
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Prognosis
Retrospective Studies
Young Adult
childhood leukemia
dexamethasone exposure
hippocampus
late effects
lymphoblastic leukemia
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
22
05
2019
revised:
09
07
2019
accepted:
30
07
2019
pubmed:
14
8
2019
medline:
6
5
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Survivors of childhood acute lymphoblastic leukemia (ALL) treated with chemotherapy only are at risk for neurocognitive impairment. Regions of interest were identified a priori based on glucocorticoid receptor distribution, and sex-stratified multivariable linear regression models were used to test associations between brain MRI morphology and total number of intrathecal injections, and serum concentration of dexamethasone and methotrexate. Compared with controls, ALL survivors have persistently smaller volumes in the bilateral cerebellum (P < 0.005), hippocampal subregions (P < 0.03), temporal lobe regions (P < 0.03), frontal lobe regions (P < 0.04), and parietal lobe regions (precuneus; P < 0.002). Long-term problems with learning may be related to residual posttreatment brain differences.
Identifiants
pubmed: 31407461
doi: 10.1002/pbc.27968
pmc: PMC6980878
mid: NIHMS1043598
doi:
Substances chimiques
Antineoplastic Agents, Hormonal
0
Dexamethasone
7S5I7G3JQL
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e27968Subventions
Organisme : NCI NIH HHS
ID : T32 CA225590
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085849
Pays : United States
Organisme : NCI NIH HHS
ID : CA21765
Pays : United States
Organisme : NIMH NIH HHS
ID : MH085849
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : CA195547
Pays : United States
Organisme : NICHD NIH HHS
ID : HD049888
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA195547
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD049888
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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