Heavy cannabis use, dependence and the brain: a clinical perspective.
brain
cannabis use disorder
cognition
neurological disorders
review
treatment
Journal
Addiction (Abingdon, England)
ISSN: 1360-0443
Titre abrégé: Addiction
Pays: England
ID NLM: 9304118
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
04
07
2019
revised:
15
07
2019
accepted:
07
08
2019
pubmed:
14
8
2019
medline:
20
2
2021
entrez:
14
8
2019
Statut:
ppublish
Résumé
To summarize and evaluate our knowledge of the relationship between heavy cannabis use, cannabis use disorder (CUD) and the brain. Narrative review of relevant literature identified through existing systematic reviews, meta-analyses and a PubMed search. Epidemiology, clinical representations, potential causal mechanisms, assessments, treatment and prognosis are discussed. Although causality is unclear, heavy and dependent cannabis use is consistently associated with a high prevalence of comorbid psychiatric disorders and learning and memory impairments that seem to recover after a period of abstinence. Evidence regarding other cognitive domains and neurological consequences, including cerebrovascular events, is limited and inconsistent. Abstinence after treatment is only achieved in a minority of cases; treatment targeted at reduction in use appears have some success. Potential moderators of the impact of CUD on the brain include age of onset, heaviness of use, CUD severity, the ratio of ∆9-tetrahydrocannabinol to cannabidiol and severity of comorbid disorders. Current evidence of long-term effects of daily cannabis use and cannabis use disorder on brain-related outcomes is suggestive rather than conclusive, but use is associated with psychiatric morbidity and with cognitive impairments that recover after a period of abstinence.
Identifiants
pubmed: 31408248
doi: 10.1111/add.14776
pmc: PMC7027478
doi:
Substances chimiques
Dronabinol
7J8897W37S
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
559-572Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042490
Pays : United States
Organisme : NIDA NIH HHS
ID : 1R01 DA042490-01A1
Pays : United States
Informations de copyright
© 2019 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
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