Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor.

Animals Aorta / drug effects Constriction Disease Models, Animal Dose-Response Relationship, Drug Fibroblasts / drug effects Fibrosis / drug therapy Male Molecular Structure Rats Rats, Sprague-Dawley Receptors, Transforming Growth Factor beta / antagonists & inhibitors Sesquiterpenes, Germacrane / chemistry Structure-Activity Relationship

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
12 09 2019
Historique:
pubmed: 14 8 2019
medline: 1 7 2020
entrez: 14 8 2019
Statut: ppublish

Résumé

A germacrane sesquiterpenoid library containing 30 compounds (

Identifiants

DOI: 10.1021/acs.jmedchem.9b00708 PMID: 31408333
pubmed: 31408333
doi: 10.1021/acs.jmedchem.9b00708
doi:

Substances chimiques

Receptors, Transforming Growth Factor beta 0
Sesquiterpenes, Germacrane 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

7961-7975

Auteurs

Lan-Lan Lou (LL)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Fu-Qiang Ni (FQ)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Lin Chen (L)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Sharpkate Shaker (S)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Wei Li (W)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Rong Wang (R)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.

Gui-Hua Tang (GH)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.
ORCID: 0000-0002-8831-7154

Sheng Yin (S)

School of Pharmaceutical Sciences , Sun Yat-Sen University , Guangzhou 510006 , People's Republic of China.
ORCID: 0000-0002-5678-6634

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Aorte › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Techniques d'investigation › Constriction › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs TGF-bêta › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Sesquiterpènes › Sesquiterpènes monocycliques › Sesquiterpènes de type germacrane › Germacrane Sesquiterpenoids as a New Type of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Germacrane Sesquiterpenoids as a New Type of...