The prokineticin receptor antagonist PC1 rescues memory impairment induced by β amyloid administration through the modulation of prokineticin system.
Alzheimer Disease
Amyloid beta-Peptides
/ toxicity
Animals
Disease Models, Animal
Gastrointestinal Hormones
/ genetics
Gliosis
Guanidines
/ pharmacology
Hippocampus
/ drug effects
Infusions, Intraventricular
Learning
/ drug effects
Male
Maze Learning
Memory
/ drug effects
NF-kappa B
/ drug effects
Neurogenesis
/ drug effects
Neuropeptides
/ drug effects
Neuroprotective Agents
/ pharmacology
Nitric Oxide Synthase Type II
/ drug effects
Peptide Fragments
/ toxicity
Rats
Receptors, G-Protein-Coupled
/ antagonists & inhibitors
Receptors, Peptide
/ antagonists & inhibitors
Reverse Transcriptase Polymerase Chain Reaction
Spatial Learning
/ drug effects
Triazines
/ pharmacology
Alzheimer's disease
Amyloid β
Animal model
Neurogenesis
Neuroprotection
Prokineticin 2
Prokineticin receptor antagonist
Prokineticin receptors
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
received:
29
11
2018
revised:
26
07
2019
accepted:
09
08
2019
pubmed:
14
8
2019
medline:
21
7
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
Growing evidences demonstrate that chemokines and chemokine receptors are up-regulated in resident central nervous system cells during Alzheimer's disease contributing to neuroinflammation and neurodegeneration. Prokineticin 2 belongs to a new family of chemokines which recently emerged as a critical player in immune system and inflammatory diseases. Since pharmacological blockade in vitro of the prokineticin system is able to antagonize Amyloid β-induced neurotoxicity, the aim of the present study was to investigate in vivo effects of prokineticin receptor antagonist PC1 on memory impairment in a rodent model of Alzheimer's disease. Rats were intracerebroventricular infused with Aβ
Identifiants
pubmed: 31408628
pii: S0028-3908(19)30298-9
doi: 10.1016/j.neuropharm.2019.107739
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Gastrointestinal Hormones
0
Guanidines
0
NF-kappa B
0
Neuropeptides
0
Neuroprotective Agents
0
PROKR1 protein, rat
0
Peptide Fragments
0
Prok2 protein, rat
0
Receptors, G-Protein-Coupled
0
Receptors, Peptide
0
Triazines
0
amyloid beta-protein (1-42)
0
prokineticin receptor 2, rat
0
Nitric Oxide Synthase Type II
EC 1.14.13.39
Nos2 protein, rat
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107739Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.