Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.
Adipogenesis
/ physiology
Animals
Bone Marrow
/ pathology
Cell Line
Cell Self Renewal
Gene Expression Profiling
Gene Expression Regulation, Developmental
Hematopoietic Stem Cells
/ cytology
Mice
Mice, Congenic
Mice, Inbred C57BL
Mice, Knockout
Polycomb Repressive Complex 1
/ deficiency
Proto-Oncogene Proteins
/ deficiency
Receptors, Leptin
/ analysis
Regeneration
Stem Cell Niche
Stromal Cells
/ chemistry
Journal
Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
27
07
2019
accepted:
30
07
2019
pubmed:
14
8
2019
medline:
18
2
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
The polycomb group protein Bmi1 maintains hematopoietic stem cell (HSC) functions. We previously reported that Bmi1-deficient mice exhibited progressive fatty changes in bone marrow (BM). A large portion of HSCs reside in the perivascular niche created partly by endothelial cells and leptin receptor
Identifiants
pubmed: 31408689
pii: S0301-472X(19)30943-9
doi: 10.1016/j.exphem.2019.07.006
pii:
doi:
Substances chimiques
Bmi1 protein, mouse
0
Proto-Oncogene Proteins
0
Receptors, Leptin
0
leptin receptor, mouse
0
Polycomb Repressive Complex 1
EC 2.3.2.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-37Informations de copyright
Copyright © 2019 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.