Redistribution, homing and organ-invasion of neoplastic stem cells in myeloid neoplasms.
Extramedullary myelopoiesis
Leukemia
Mast cell sarcoma
Myeloid sarcoma
Neoplastic stem cells
Stem cell invasion
Stem cell niche
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
01
07
2019
revised:
30
07
2019
accepted:
30
07
2019
pubmed:
14
8
2019
medline:
18
12
2020
entrez:
14
8
2019
Statut:
ppublish
Résumé
The development of a myeloid neoplasm is a step-wise process that originates from leukemic stem cells (LSC) and includes pre-leukemic stages, overt leukemia and a drug-resistant terminal phase. Organ-invasion may occur in any stage, but is usually associated with advanced disease and a poor prognosis. Sometimes, extra-medullary organ invasion shows a metastasis-like or even sarcoma-like destructive growth of neoplastic cells in local tissue sites. Examples are myeloid sarcoma, mast cell sarcoma and localized blast phase of chronic myeloid leukemia. So far, little is known about mechanisms underlying re-distribution and extramedullary dissemination of LSC in myeloid neoplasms. In this article, we discuss mechanisms through which LSC can mobilize out of the bone marrow niche, can transmigrate from the blood stream into extramedullary organs, can invade local tissue sites and can potentially create or support the formation of local stem cell niches. In addition, we discuss strategies to interfere with LSC expansion and organ invasion by targeted drug therapies.
Identifiants
pubmed: 31408723
pii: S1044-579X(19)30214-7
doi: 10.1016/j.semcancer.2019.07.025
pmc: PMC7115853
mid: EMS87366
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-201Subventions
Organisme : Austrian Science Fund FWF
ID : F 4704
Pays : Austria
Organisme : Austrian Science Fund FWF
ID : P 30625
Pays : Austria
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict to disclose in this study.
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