MiR-574-5p: A Circulating Marker of Thoracic Aortic Aneurysm.
biomarker
circulating microRNAs
thoracic aortic aneurysm
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 08 2019
12 08 2019
Historique:
received:
01
07
2019
revised:
07
08
2019
accepted:
09
08
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
16
1
2020
Statut:
epublish
Résumé
Thoracic aortic aneurysm (TAA) can lead to fatal complications such as aortic dissection. Since aneurysm dimension poorly predicts dissection risk, microRNAs (miRNAs) may be useful to diagnose or risk stratify TAA patients. We aim to identify miRNAs associated with TAA pathogenesis and that are possibly able to improve TAA diagnosis. MiRNA microarray experiments of aortic media tissue samples from 19 TAA patients and 19 controls allowed identifying 232 differentially expressed miRNAs. Using interaction networks between these miRNAs and 690 genes associated with TAA, we identified miR-574-5p as a potential contributor of TAA pathogenesis. Interestingly, miR-574-5p was significantly down-regulated in the TAA tissue compared to the controls, but was up-regulated in serum samples from a separate group of 28 TAA patients compared to 20 controls (
Identifiants
pubmed: 31409059
pii: ijms20163924
doi: 10.3390/ijms20163924
pmc: PMC6720007
pii:
doi:
Substances chimiques
Biomarkers
0
MIRN574 microRNA, human
0
MIRN574 microRNA, mouse
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fonds National de la Recherche Luxembourg
ID : AFR 8832104
Pays : International
Organisme : Fredman Fellowship
ID : na
Pays : International
Organisme : Toomey Fund for Aortic Dissection Research
ID : na
Pays : International
Organisme : Hassenfeld Fellowship
ID : na
Pays : International
Organisme : Aneurysmal Pathology Foundation
ID : na
Pays : International
Organisme : NIH HHS
ID : #HL130113
Pays : United States
Organisme : Toomey Fund for Aortic Dissection Research
ID : na
Pays : International
Organisme : Ministère de l'Enseignement Supérieur et de la Recherche
ID : Luxembourg
Pays : International
Organisme : NHLBI NIH HHS
ID : RO1-HL22547
Pays : United States
Organisme : Fonds pour la chirurgie cardiaque, ASBL
ID : na
Pays : International
Organisme : European Program FP7 "Fighting aneurysmal diseases"
ID : 200647
Pays : International
Organisme : Institut National de la Santé et de la Recherche Médicale
ID : na
Pays : International
Organisme : Agence Nationale pour la Recherche GDPMs
ID : na
Pays : International
Organisme : NONAGES
ID : na
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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