Prognostic significance of neutrophil-lymphocyte ratio in resectable pancreatic neuroendocrine tumors with special reference to tumor-associated macrophages.
Adult
Aged
Disease-Free Survival
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Leukocyte Count
Lymphatic Metastasis
Lymphocyte Count
Macrophages
/ pathology
Male
Middle Aged
Neoplasm Recurrence, Local
Neuroendocrine Tumors
/ blood
Neutrophils
Pancreatectomy
Pancreatic Neoplasms
/ blood
Predictive Value of Tests
Prognosis
Retrospective Studies
Systemic Inflammatory Response Syndrome
/ epidemiology
Treatment Outcome
Neutrophil-to-lymphocyte ratio
Tumor-associated macrophage
pancreatic neuroendocrine tumor
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ISSN: 1424-3911
Titre abrégé: Pancreatology
Pays: Switzerland
ID NLM: 100966936
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
28
02
2019
revised:
06
08
2019
accepted:
07
08
2019
pubmed:
15
8
2019
medline:
25
2
2020
entrez:
15
8
2019
Statut:
ppublish
Résumé
Recent studies have shown that the systemic inflammatory response induced by cancer leads to cancer progression. Neutrophil-to-lymphocyte ratio (NLR) is the most reliable marker to detect systemic inflammation. In this study, we investigated the significance of NLR in patients with well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization 2017 classification. We retrospectively collected data for patients with PanNET who underwent pancreatic resection with curative intent between January 2008 and December 2017 at six institutions. Clinicopathological factors, recurrence, and immunohistochemical staining of tumor-associated macrophages (TAMs) were analyzed in a total of 55 patients in this study. High NLR (>3.41) in patients was significantly associated with higher white blood cell count, higher Ki-67 index, higher mitotic count, higher grade, higher incidence of lymph node metastasis, higher incidence of lymphatic and neural invasion, massive blood loss, and a large number of CD163-expressing TAMs. Recurrence-free survival of patients with high NLR was significantly poorer than that of patients with low NLR. Multivariate analysis identified high NLR, NET Grade 2 (G2) or Grade 3 (G3), and synchronous hepatic resection as independent risk factors for recurrence after curative resection. NLR is a promising predictor of recurrence after pancreatectomy that needs to be further investigated and that accumulation of TAMs in the tumor could be one of the causes of NLR elevation.
Sections du résumé
BACKGROUND
BACKGROUND
Recent studies have shown that the systemic inflammatory response induced by cancer leads to cancer progression. Neutrophil-to-lymphocyte ratio (NLR) is the most reliable marker to detect systemic inflammation. In this study, we investigated the significance of NLR in patients with well-differentiated pancreatic neuroendocrine tumors (PanNETs) according to the World Health Organization 2017 classification.
METHODS
METHODS
We retrospectively collected data for patients with PanNET who underwent pancreatic resection with curative intent between January 2008 and December 2017 at six institutions. Clinicopathological factors, recurrence, and immunohistochemical staining of tumor-associated macrophages (TAMs) were analyzed in a total of 55 patients in this study.
RESULTS
RESULTS
High NLR (>3.41) in patients was significantly associated with higher white blood cell count, higher Ki-67 index, higher mitotic count, higher grade, higher incidence of lymph node metastasis, higher incidence of lymphatic and neural invasion, massive blood loss, and a large number of CD163-expressing TAMs. Recurrence-free survival of patients with high NLR was significantly poorer than that of patients with low NLR. Multivariate analysis identified high NLR, NET Grade 2 (G2) or Grade 3 (G3), and synchronous hepatic resection as independent risk factors for recurrence after curative resection.
CONCLUSIONS
CONCLUSIONS
NLR is a promising predictor of recurrence after pancreatectomy that needs to be further investigated and that accumulation of TAMs in the tumor could be one of the causes of NLR elevation.
Identifiants
pubmed: 31409525
pii: S1424-3903(19)30684-2
doi: 10.1016/j.pan.2019.08.003
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
897-902Informations de copyright
Copyright © 2019 IAP and EPC. Published by Elsevier B.V. All rights reserved.