Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential.
Angiopellosis
Cancer exodus hypothesis
Circulating tumor cell cluster
Metastasis
Tumor cell extravasation
Journal
Journal of cell science
ISSN: 1477-9137
Titre abrégé: J Cell Sci
Pays: England
ID NLM: 0052457
Informations de publication
Date de publication:
09 09 2019
09 09 2019
Historique:
received:
04
03
2019
accepted:
25
07
2019
pubmed:
15
8
2019
medline:
15
8
2020
entrez:
15
8
2019
Statut:
epublish
Résumé
Metastasis accounts for the majority of all cancer deaths, yet the process remains poorly understood. A pivotal step in the metastasis process is the exiting of tumor cells from the circulation, a process known as extravasation. However, it is unclear how tumor cells extravasate and whether multicellular clusters of tumor cells possess the ability to exit as a whole or must first disassociate. In this study, we use
Identifiants
pubmed: 31409692
pii: jcs.231563
doi: 10.1242/jcs.231563
pmc: PMC6771143
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NCI NIH HHS
ID : F31 CA217153
Pays : United States
Organisme : NIH HHS
ID : K01 OD021419
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137093
Pays : United States
Informations de copyright
© 2019. Published by The Company of Biologists Ltd.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing or financial interests.
Références
Cell. 2014 Aug 28;158(5):1110-1122
pubmed: 25171411
Clin Exp Metastasis. 1986 Oct-Dec;4(4):273-84
pubmed: 3791726
Transl Oncol. 2016 Aug;9(4):340-7
pubmed: 27567958
Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):407-12
pubmed: 15630097
Am J Pathol. 2011 Mar;178(3):989-96
pubmed: 21356352
Cell Commun Signal. 2008 Dec 04;6:10
pubmed: 19055814
Clin Exp Metastasis. 2008;25(4):305-24
pubmed: 17906932
ILAR J. 2017 Jul 1;58(1):4-16
pubmed: 28838067
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Trends Cancer. 2015 Sep;1(1):44-52
pubmed: 28741562
Trends Cell Biol. 2013 Dec;23(12):584-6
pubmed: 24275383
Cell. 2019 Jan 10;176(1-2):98-112.e14
pubmed: 30633912
Nat Rev Clin Oncol. 2019 Mar;16(3):185-204
pubmed: 30514977
Dev Cell. 2013 Jun 10;25(5):492-506
pubmed: 23763948
Proc Natl Acad Sci U S A. 2016 May 3;113(18):4947-52
pubmed: 27091969
Gan. 1984 Jun;75(6):534-9
pubmed: 6088347
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Dev Biol. 2008 Apr 15;316(2):312-22
pubmed: 18342303
Cancer Res. 1974 May;34(5):997-1004
pubmed: 4841969
Nat Methods. 2010 Feb;7(2):92-3
pubmed: 20111033
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21677-82
pubmed: 21098274
J Pathol. 2012 Jan;226(2):380-93
pubmed: 21953325
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19350-5
pubmed: 20974951
Stem Cells. 2017 Jan;35(1):170-180
pubmed: 27350343
Front Physiol. 2016 Mar 08;7:56
pubmed: 27014075
Cold Spring Harb Perspect Med. 2012 May;2(5):a006684
pubmed: 22553495
Neoplasia. 2009 Jul;11(7):651-61
pubmed: 19568410
Br J Cancer. 1983 Nov;48(5):665-73
pubmed: 6639858
Neoplasia. 2005 May;7(5):522-7
pubmed: 15967104
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18392-7
pubmed: 20930119