Cerumenogram: a new frontier in cancer diagnosis in humans.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
received:
31
01
2019
accepted:
22
07
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
27
10
2020
Statut:
epublish
Résumé
Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.
Identifiants
pubmed: 31409861
doi: 10.1038/s41598-019-48121-4
pii: 10.1038/s41598-019-48121-4
pmc: PMC6692389
doi:
Substances chimiques
Biomarkers
0
Volatile Organic Compounds
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11722Références
J Chem Ecol. 2015 Jan;41(1):67-74
pubmed: 25501636
Eur J Cancer. 2018 Nov;103:317-326
pubmed: 29903684
PLoS One. 2012;7(1):e30181
pubmed: 22291914
Anal Bioanal Chem. 2018 Jun;410(16):3671-3681
pubmed: 29654337
Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85
pubmed: 17712357
Prostate. 2011 May 15;71(7):700-10
pubmed: 20957673
Sci Transl Med. 2012 Mar 28;4(127):127rv3
pubmed: 22461644
FASEB J. 2007 Jun;21(8):1675-88
pubmed: 17314143
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 15;877(28):3366-77
pubmed: 19505855
Chem Biol Interact. 2001 Jun 1;135-136:223-38
pubmed: 11397393
J Breath Res. 2014 Mar;8(1):014001
pubmed: 24421258
Clin Biochem. 2012 Jan;45(1-2):127-33
pubmed: 22061338
Sci Adv. 2016 Mar 18;2(3):e1501473
pubmed: 27034986
J Chromatogr A. 2003 Jan 24;985(1-2):303-12
pubmed: 12580498
J Laryngol Otol. 2008 Sep;122(9):881-6
pubmed: 17931445
Toxicol Sci. 2000 Sep;57(1):4-5
pubmed: 10966505
PLoS One. 2017 Aug 25;12(8):e0183538
pubmed: 28841695
Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11036-48
pubmed: 26235374
Cell. 2011 Mar 4;144(5):646-74
pubmed: 21376230
J Breath Res. 2018 Jul 30;12(4):046005
pubmed: 29893713
Future Sci OA. 2016 Jun 10;2(2):FSO106
pubmed: 28031956
Chem Rev. 2017 May 10;117(9):6399-6422
pubmed: 28306239
Science. 2018 Feb 23;359(6378):926-930
pubmed: 29348365
Biochim Biophys Acta. 1994 Sep 15;1214(2):209-20
pubmed: 7918602
J Breath Res. 2014 Jun;8(2):027111
pubmed: 24862102
Appl Environ Microbiol. 2014 Jun;80(11):3416-25
pubmed: 24657864
J Clin Oncol. 2008 Aug 20;26(24):4012-21
pubmed: 18711192
Brain. 2001 Jul;124(Pt 7):1426-37
pubmed: 11408337
Gut. 2015 Mar;64(3):447-58
pubmed: 24811995
J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 15;953-954:48-52
pubmed: 24572763
Chem Biol Interact. 2001 Dec 21;138(3):247-65
pubmed: 11714482
Sci Adv. 2018 Apr 18;4(4):eaaq1090
pubmed: 29675469
Metabolites. 2015 Jan 09;5(1):3-55
pubmed: 25584743
Anal Chim Acta. 2018 Sep 6;1023:53-63
pubmed: 29754607
Carcinogenesis. 2014 Sep;35(9):2089-96
pubmed: 25037050
Clin Cancer Res. 2018 Oct 15;24(20):5133-5142
pubmed: 29950348
Curr Med Chem. 2016;23(20):2112-31
pubmed: 27160536
Anal Bioanal Chem. 2018 Jul;410(18):4459-4468
pubmed: 29732495
PLoS One. 2011 Apr 08;6(4):e18471
pubmed: 21494609
QJM. 2004 Aug;97(8):477-88
pubmed: 15256605
Forensic Toxicol. 2017;35(2):348-358
pubmed: 28912899
Sci Transl Med. 2011 Nov 16;3(109):109ra116
pubmed: 22089452
J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Dec 25;813(1-2):59-65
pubmed: 15556516
Nat Commun. 2018 Nov 2;9(1):4587
pubmed: 30389921
J Proteomics. 2017 Apr 21;159:92-101
pubmed: 28286320
Rapid Commun Mass Spectrom. 2011 Aug 15;25(15):2163-72
pubmed: 21710596
J Breath Res. 2009 Jun;3(2):027003
pubmed: 21383458
Toxicon. 2017 Oct;137:54-57
pubmed: 28716647
Science. 2018 Oct 12;362(6411):
pubmed: 30309915
Urol Oncol. 2018 May;36(5):243.e21-243.e27
pubmed: 29395956
J Breath Res. 2012 Jun;6(2):027108
pubmed: 22621865
Cancer Metab. 2016 Jun 06;4:11
pubmed: 27275383
Proc Natl Acad Sci U S A. 2018 May 29;115(22):5780-5785
pubmed: 29760095
Otolaryngol Head Neck Surg. 2017 Jan;156(1_suppl):S1-S29
pubmed: 28045591
Aliment Pharmacol Ther. 2016 Mar;43(5):596-611
pubmed: 26806034
Sci Transl Med. 2010 Aug 4;2(43):43ra55
pubmed: 20686178
Nat Commun. 2018 Oct 17;9(1):4319
pubmed: 30333487
J Breath Res. 2014 Jun;8(2):027109
pubmed: 24861817
Biochem Med (Zagreb). 2017 Oct 15;27(3):030503
pubmed: 29180914
J Chromatogr A. 2007 Jul 27;1158(1-2):318-28
pubmed: 17466315
J Chem Ecol. 2010 Sep;36(9):1035-42
pubmed: 20809147
Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):697-720
pubmed: 18611112
Microorganisms. 2015 Nov 12;3(4):866-89
pubmed: 27682122
Clin Microbiol Rev. 2013 Jul;26(3):462-75
pubmed: 23824368
PLoS One. 2016 Mar 25;11(3):e0152126
pubmed: 27015276
Br J Cancer. 2011 Dec 6;105(12):1894-904
pubmed: 22085842
Neoplasia. 2017 Oct;19(10):848-855
pubmed: 28923537
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
PLoS One. 2013 Aug 06;8(8):e70803
pubmed: 23940645
Talanta. 2012 Jan 30;89:360-8
pubmed: 22284503
Int J Cancer. 2011 Nov 1;129(9):2207-17
pubmed: 21190195
Toxicol Lett. 2014 Jan 3;224(1):47-53
pubmed: 24140552
Aliment Pharmacol Ther. 2018 Jul;48(1):15-34
pubmed: 29722430
Metabolomics. 2010 Mar;6(1):78-95
pubmed: 20300169
J Proteome Res. 2012 Feb 3;11(2):1354-63
pubmed: 22148915
Eur J Med Chem. 2015 Jul 15;100:176-87
pubmed: 26087028
Chem Rev. 2012 Nov 14;112(11):5949-66
pubmed: 22991938