Effect of surgical intraocular pressure lowering on retinal structures - nerve fibre layer, foveal avascular zone, peripapillary and macular vessel density: 1 year results.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
17
12
2018
accepted:
11
07
2019
revised:
16
06
2019
pubmed:
15
8
2019
medline:
22
6
2021
entrez:
15
8
2019
Statut:
ppublish
Résumé
To determine the effect of surgical intraocular pressure (IOP) lowering on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT-A). This was a prospective observational study performed at the Glaucoma Research Centre, Montchoisi Clinic, Lausanne. In total 40 eyes with open-angle glaucoma were included. OCT-A scans were performed before glaucoma surgery, and at 1-month, 3-month, 6-month, and 12-month post-operatively. AngioVue AngioAnalytic (Optovue Inc, Fremont, CA) software was used to analyse the RNFL, FAZ, peripapillary and macular VD. Changes were analysed using analysis of variance (ANOVA) models. Mean IOP dropped from 19.4 (±7.0) mmHg pre-surgery and stabilized at 13.0 (±3.1) mmHg at 12 months (p < 0.001). The number of topical medications reduced from 2.2 (±1.2) preoperatively to 0.4 (±0.8) at 1 year (p < 0.001). Peripapillary RNFL thickness was transiently increased at 1-month postoperatively (p = 0.03). Peripapillary VD fluctuated throughout the follow-up. Foveal VD showed increased perfusion at 3 and 6 months post-operatively with minimal changes at 1 month (p < 0.01). Glaucoma surgery had a significant effect initially on FAZ area (p = 0.03), FAZ perimeter (p = 0.02) and Acircularity Index (AI) (p = 0.04). By 12-months FAZ measurements had reversed to baseline values. Peripapillary and macular microcirculations responded differently to surgically induced IOP reduction. Peripapillary microcirculation was IOP-independent within the studied range of surgically-controlled IOP. Macular microcirculation, however, exhibited a "delayed response" followed by near-normal reperfusion after glaucoma surgery. FAZ parameters could be potentially useful modalities to assess vascular reperfusion after glaucoma surgery as, amongst all studied parameters, the area was the most sensitive to surgically induced IOP changes.
Identifiants
pubmed: 31409906
doi: 10.1038/s41433-019-0560-6
pii: 10.1038/s41433-019-0560-6
pmc: PMC7042361
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
562-571Commentaires et corrections
Type : CommentIn
Type : CommentIn
Références
Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714–20.
pubmed: 12049575
Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:701–13.
pubmed: 12049574
The AGIS Investigators. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429–40.
Leske MC, Heijl A, Hussein M, et al. Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol. 2003;121:48–56.
pubmed: 12523884
Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol. 1991;109:77–83.
pubmed: 1987954
Schmidl D, Garhofer G, Schmetterer L. The complex interaction between ocular perfusion pressure and ocular blood flow—relevance for glaucoma. Exp Eye Res. 2011;93:141–55.
pubmed: 20868686
Flammer J, Orgul S, Costa VP, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–93.
pubmed: 12150988
Bonomi L, Marchini G, Marraffa M, et al. Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study. Ophthalmology. 2000;107:1287–93.
pubmed: 10889099
Heijl A, Leske MC, Bengtsson B, et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002;120:1268–79.
pubmed: 12365904
Akagi T, Iida Y, Nakanishi H, et al. Microvascular density in glaucomatous eyes with hemifield visual field defects: an optical coherence tomography angiography study. Am J Ophthalmol. 2016;168:237–249.36.
pubmed: 27296492
Lommatzsch C, Rothaus K, Koch JM, Heinz C, Grisanti S. OCTA vessel density changes in the macular zone in glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol. 2018;256:1499–508.
pubmed: 29637255
Tan ACS, Tan GS, Denniston AK, Keane PA, Ang M, Milea D, et al. An overview of the clinical applications of optical coherence tomography angiography. Eye (Lond). 2018;32:262–86.
Gherghel D, Orgül S, Gugleta K, et al. Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage. Am J Ophthalmol. 2000;130:597–605.
pubmed: 11078838
Leske MC. Ocular perfusion pressure and glaucoma: clinical trial and epidemiologic findings. Curr Opin Ophthalmoll. 2009;20:73–78.
Rosenfeld PJ, Durbin MK, Roisman L, et al. ZEISS Angioplex spectral domain optical coherence tomography angiography: technical aspects. Dev Ophthalmol. 2016;56:18–29.
pubmed: 27023249
Chang RT, Knight OJ, Feuer WJ, et al. Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma. Ophthalmology. 2009;116:2294–9.
pubmed: 19800694
Leung CK, Cheung CY, Weinreb RN, et al. Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology. 2009;116:1257–63. 63.e1-2
pubmed: 19464061
Kuerten D, Fuest M, Koch EC, et al. Long term effect of trabeculectomy on retrobulbar haemodynamics in glaucoma. Ophthalmic Physiol Opt. 2015;35:194–200.
pubmed: 25529068
Berisha F, Schmetterer K, Vass C, et al. Effect of trabeculectomy on ocular blood flow. Br J Ophthalmol. 2005;89:185–8.
pubmed: 15665350
pmcid: 1772494
Januleviciene I, Siaudvytyte L, Diliene V, et al. Effect of trabeculectomy on ocular hemodynamic parameters in pseudoexfoliative and primary open-angle glaucoma patients. J Glaucoma. 2015;24:e52–e56.
pubmed: 24844536
Trible JR, Sergott RC, Spaeth GL, et al. Trabeculectomy is associated with retrobulbar hemodynamic changes. A color Doppler analysis. Ophthalmology. 1994;101:340–51.
pubmed: 8115155
Poinoosawmy D, Indar A, Bunce C, et al. Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma. Graefes Arch Clin Exp Ophthalmol. 2002;240:721–6.
pubmed: 12271368
Zéboulon P, Léveque PM, Brasnu E, et al. Effect of Surgical Intraocular Pressure Lowering on Peripapillary and Macular Vessel Density in Glaucoma Patients: An Optical Coherence Tomography Angiography Study. J Glaucoma. 2017;26:466–72.
pubmed: 28234681
de Carlo TE, Romano A, Waheed NK, Duker JS. A review of optical coherence tomography angiography (OCTA). Int J Retin Vitr. 2015;1:5. Published2015
RTVue XR Avanti User Manual International Software Version2017.1 With DualTrac P/N 580-51219-005 Rev A. Optovue, Inc 2800 Bayview Drive Fremont, CA 94538, USA.
Chee SP, Ti SE, Sivakumar M, et al. Postoperative inflammation: extracapsular cataract extraction versus phacoemulsification. J Cataract Refract Surg. 1999;25:1280–5.
pubmed: 10476515
Xu H, Chen M, Forrester JV, et al. Cataract surgery induces retinal pro-inflammatory gene expression and protein secretion. Invest Ophthalmol Vis Sci. 2011;52:249–55.
pubmed: 20720227
Bhagat K, Hingorani AD, Palacios M, et al. Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS. Cardiovasc Res. 1999;41:754–64.
pubmed: 10435048
Zhao Z, Wen W, Jiang C, et al. Changes in macular vasculature after uncomplicated phacoemulsification surgery: optical coherence tomography angiography study. J Cataract Refract Surg. 2018;44:453–8.
pubmed: 29705010
Raghu N, Pandav SS, Kaushik S, et al. Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography. Eye. 2012;26:1131–7.
pubmed: 22722487
pmcid: 3420047
Hollo Gabor. Influence of large intraocular pressure reduction on peripapillary OCT vessel density in ocular hypertensive and glaucoma eyes eyes. J Glaucoma. 2017;26:e7–e10.
pubmed: 27571444
Hollò G. Optical coherence tomography angiography in glaucoma. Turk J Ophthalmol. 2018;48:196–201.
pubmed: 30202616
pmcid: 6126098
Alnawaiseh M, Müller V, Lahme L, Merté RL, Eter N. Changes in flow density measured using optical coherence tomography angiography after iStent insertion in combination with phacoemulsification in patients with open-angle Glaucoma. J Ophthalmol. 2018;2018:2890357.
pubmed: 29651340
pmcid: 5831894
Hafez AS, RLG Bizzarro, Rivard M, et al. Changes in optic nerve head blood flow after therapeutic intraocular pressure reduction in glaucoma patients and ocular hypertensives. Ophthalmology. 2003;110:201–10.
pubmed: 12511367
Trible JR, Costa VP, Sergott RC, et al. The influence of primary open-angle glaucoma upon the retrobulbar circulation: baseline, postoperative and reproducibility analysis. Trans Am Ophthalmol Soc. 1993;91:245–61. 261–265
pubmed: 8140694
pmcid: 1298469
James CB. Effect of trabeculectomy on pulsatile ocular blood flow. Br J Ophthalmol. 1994;78:818–22.
pubmed: 7848975
pmcid: 504963
Ghassemi F, Fadakar K, Bazvand F, et al. The quantitative measurements of vascular density and flow areas of macula using optical coherence tomography angiography in normal volunteers. Ophthalmic Surg Lasers Imaging Retin. 2017;48:478–86.
Tielsch JamesM, Katz Joanne, Sommer Alfred, et al. Hypertension, perfusion pressure, and primary open-angle glaucomaa population-based assessment. Arch Ophthalmol. 1995;113:216–21.
pubmed: 7864755
Jonas JB, Schneider U, Naumann GO. Count and density of human retinal photoreceptors. Graefes Arch Clin Exp Ophthalmol. 1992;230:505–10.
pubmed: 1427131
Yu DY, Cringle SJ, Su EN. Intraretinal oxygen distribution in the monkey retina and the response to systemic hyperoxia. Invest Ophthalmol Vis Sci. 2005;46:4728–33.
pubmed: 16303972
Ghassemi F, Mirshahi R, Bazvand F, et al. The quantitative measurements of foveal avascular zone using optical coherence tomography angiography in normal volunteers. J Curr Ophthalmol. 2017;29:293–9.
pubmed: 29270477
pmcid: 5735238
Zivkovic M, Dayanir V, Kocaturk T, et al. Foveal avascular zone in normal tension glaucoma measured by optical coherence tomography angiography. Biomed Res Int. 2017;3079141:7.
Kwon J, Choi J, Shin JW, et al. Alterations of the foveal avascular zone measured by optical coherence tomography angiography in glaucoma patients with central visual field defects. Invest Ophthalmol Vis Sci. 2017;58:1637–45.
pubmed: 28297029
Costa VitalP, Harris Alon, Anderson Douglas, et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmol. 2014;92:e252–e266.
pubmed: 24238296
Gao SimonS, Liu Gangjun, Huang David, et al. Optimization of the split-spectrum amplitude-decorrelation angiography algorithm on a spectral optical coherence tomography system. Opt Lett. 2015;40:2305–8.
pubmed: 26393725
pmcid: 4581446