Quantitative CT analysis in patients with pulmonary emphysema: is lung function influenced by concomitant unspecific pulmonary fibrosis?
Aged
Correlation of Data
Female
Humans
Lung
/ diagnostic imaging
Lung Volume Measurements
/ methods
Male
Middle Aged
Patient Acuity
Pulmonary Disease, Chronic Obstructive
/ complications
Pulmonary Emphysema
/ diagnostic imaging
Pulmonary Fibrosis
/ diagnostic imaging
Respiratory Function Tests
/ methods
Severity of Illness Index
Tomography, X-Ray Computed
/ methods
COPD
CPFE
pulmonary emphysema
pulmonary fibrosis
quantitative CT
Journal
International journal of chronic obstructive pulmonary disease
ISSN: 1178-2005
Titre abrégé: Int J Chron Obstruct Pulmon Dis
Pays: New Zealand
ID NLM: 101273481
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
02
2019
accepted:
16
05
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
8
2
2020
Statut:
epublish
Résumé
Quantitative analysis of CT scans has proven to be a reproducible technique, which might help to understand the pathophysiology of chronic obstructive pulmonary disease (COPD) and combined pulmonary fibrosis and emphysema. The aim of this retrospective study was to find out if the lung function of patients with COPD with Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages III or IV and pulmonary emphysema is measurably influenced by high attenuation areas as a correlate of concomitant unspecific fibrotic changes of lung parenchyma. Eighty-eight patients with COPD GOLD stage III or IV underwent CT and pulmonary function tests. Quantitative CT analysis was performed to determine low attenuation volume (LAV) and high attenuation volume (HAV), which are considered to be equivalents of fibrotic (HAV) and emphysematous (LAV) changes of lung parenchyma. Both parameters were determined for the whole lung, as well as peripheral and central lung areas only. Multivariate regression analysis was used to correlate HAV with different parameters of lung function. Unlike LAV, HAV did not show significant correlation with parameters of lung function. Even in patients with a relatively high HAV of more than 10%, in contrast to HAV ( In patients with COPD GOLD stage III-IV, emphysematous changes of lung parenchyma seem to have such a strong influence on lung function, which is a possible effect of concomitant unspecific fibrosis is overwhelmed.
Identifiants
pubmed: 31409984
doi: 10.2147/COPD.S204007
pii: 204007
pmc: PMC6646798
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1583-1593Déclaration de conflit d'intérêts
Dr. Jan-Martin Kuhnigk reports a patent US20050196024A1 issued. The authors report no other conflicts of interest in this work.
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