HIF-1α/Wnt signaling-dependent control of gene transcription regulates neuronal differentiation of glioblastoma stem cells.
Brain Neoplasms
/ genetics
Cell Hypoxia
Gene Expression Regulation, Neoplastic
Glioblastoma
/ genetics
Hepatocyte Nuclear Factor 1-alpha
/ genetics
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
/ genetics
Neoplastic Stem Cells
/ cytology
Neurogenesis
Neurons
/ cytology
Oxygen
/ metabolism
Tumor Cells, Cultured
Wnt Signaling Pathway
Cancer stem cells
HIF-1α
glioblastoma
neuronal differentiation.
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
04
2019
accepted:
05
06
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
21
8
2020
Statut:
epublish
Résumé
HIF-1α has been suggested to interplay with Wnt signaling components in order to activate a neuronal differentiation process in both normal brain and glioblastoma (GBM). Based on these data, we explored the molecular mechanisms underlying the observed capability of GBM cells to acquire a neuronal phenotype upon Wnt signaling stimulation and how the microenvironment, particularly hypoxia, modulates this process.
Identifiants
pubmed: 31410187
doi: 10.7150/thno.35882
pii: thnov09p4860
pmc: PMC6691379
doi:
Substances chimiques
HIF1A protein, human
0
HNF1A protein, human
0
Hepatocyte Nuclear Factor 1-alpha
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4860-4877Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
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