The long noncoding RNA CHROME regulates cholesterol homeostasis in primate.

Animals Atherosclerosis / genetics Cholesterol / metabolism Hepatocytes / metabolism Homeostasis Humans Lipid Metabolism Liver X Receptors / metabolism MicroRNAs / genetics Primates / genetics RNA, Long Noncoding / genetics

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
01 2019
Historique:
entrez: 15 8 2019
pubmed: 15 8 2019
medline: 15 8 2019
Statut: ppublish

Résumé

The human genome encodes thousands of long non-coding RNAs (lncRNAs), the majority of which are poorly conserved and uncharacterized. Here we identify a primate-specific lncRNA (

Identifiants

DOI: 10.1038/s42255-018-0004-9 PMID: 31410392 PMC: PMC6691505
pubmed: 31410392
doi: 10.1038/s42255-018-0004-9
pmc: PMC6691505
mid: NIHMS1509876
doi:

Substances chimiques

Liver X Receptors 0
MicroRNAs 0
RNA, Long Noncoding 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

98-110

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL119047
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL114978
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL131481
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL129433
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL098129
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111932
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127173
Pays : United States
Organisme : NHLBI NIH HHS
ID : P30 HL101270
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK105965
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL088528
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY001711
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL116263
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117226
Pays : United States
Organisme : NHLBI NIH HHS
ID : K22 HL113039
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128996
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135799
Pays : United States

Commentaires et corrections

Type : CommentIn

Déclaration de conflit d'intérêts

Competing Interests: KJM and New York University hold a patent (US 9241950, Status: issued 1/26/2016) on the use of miR-33 inhibitors to treat inflammation. All other authors have no competing interests.

Références

J Biol Chem. 1957 May;226(1):497-509
pubmed: 13428781
BMC Genet. 2003 Dec 31;4 Suppl 1:S98
pubmed: 14975166
Cell Tissue Bank. 2003;4(1):49-56
pubmed: 15256870
J Cell Biol. 2004 Oct 25;167(2):269-79
pubmed: 15504910
Nat Cell Biol. 2005 Jul;7(7):719-23
pubmed: 15937477
Eur J Hum Genet. 2007 Mar;15(3):313-9
pubmed: 17149386
Methods Cell Biol. 1991;35:73-99
pubmed: 1723481
Curr Protoc Cell Biol. 2007 Jun;Chapter 24:Unit 24.2
pubmed: 18228510
Endocrinology. 2009 Apr;150(4):1766-74
pubmed: 19131569
Science. 2010 Jun 18;328(5985):1566-9
pubmed: 20466882
Science. 2010 Jun 18;328(5985):1570-3
pubmed: 20466885
Science. 2010 Jun 18;328(5985):1534-9
pubmed: 20558712
Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12228-32
pubmed: 20566875
FASEB J. 2011 Feb;25(2):444-8
pubmed: 20956613
Cell. 2011 Apr 29;145(3):341-55
pubmed: 21529710
Proc Natl Acad Sci U S A. 2011 May 31;108(22):9232-7
pubmed: 21576456
J Clin Invest. 2011 Jul;121(7):2921-31
pubmed: 21646721
Cell Mol Life Sci. 2012 Mar;69(6):915-30
pubmed: 22009455
Nature. 2011 Oct 19;478(7369):404-7
pubmed: 22012398
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):196-206
pubmed: 22258902
Neuron. 2012 May 10;74(3):453-66
pubmed: 22578497
EMBO Mol Med. 2012 Sep;4(9):882-95
pubmed: 22767443
Hepatology. 2013 Feb;57(2):533-42
pubmed: 22777896
Physiol Rev. 2012 Jul;92(3):1061-85
pubmed: 22811425
Methods. 2012 Oct;58(2):81-7
pubmed: 22813890
Circ Res. 2013 Jun 7;112(12):1592-601
pubmed: 23519695
Circ Res. 2013 Jun 7;112(12):1602-12
pubmed: 23519696
PLoS Genet. 2013 Apr;9(4):e1003470
pubmed: 23637635
Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2432-43
pubmed: 23908247
PLoS One. 2013 Sep 09;8(9):e73240
pubmed: 24039891
Circ Res. 2014 Jan 3;114(1):157-70
pubmed: 24385509
Circ Res. 2014 Jan 3;114(1):183-92
pubmed: 24385511
Mol Cancer. 2014 Apr 28;13:92
pubmed: 24775712
Nat Rev Genet. 2015 Feb;16(2):113-26
pubmed: 25488579
Genome Biol. 2015 Jan 29;16:20
pubmed: 25630241
Front Genet. 2015 Jan 26;6:2
pubmed: 25674102
Atherosclerosis. 2015 Sep;242(1):29-36
pubmed: 26164157
Curr Opin Cardiol. 2015 Sep;30(5):536-42
pubmed: 26192490
Nat Med. 2015 Nov;21(11):1290-7
pubmed: 26501192
Atherosclerosis. 2015 Dec;243(2):499-509
pubmed: 26520906
Nucleic Acids Res. 2016 Jan 29;44(2):863-77
pubmed: 26578588
J Intern Med. 2016 Mar;279(3):293-308
pubmed: 26620734
Nat Rev Genet. 2016 Jan;17(1):47-62
pubmed: 26666209
Circ Res. 2016 Feb 19;118(4):703-20
pubmed: 26892968
Sci Rep. 2016 Mar 03;6:22640
pubmed: 26935028
Arterioscler Thromb Vasc Biol. 2016 May;36(5):942-951
pubmed: 26941018
Cell Mol Life Sci. 2016 Jul;73(13):2491-509
pubmed: 27007508
Nature. 2016 May 11;534(7605):124-8
pubmed: 27251289
Nat Rev Genet. 2016 Oct;17(10):601-14
pubmed: 27573374
Blood. 2016 Oct 20;128(16):2033-2042
pubmed: 27609643
Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):21-25
pubmed: 27856459
Int J Biol Sci. 2017 Feb 25;13(3):349-357
pubmed: 28367099
Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1058-1067
pubmed: 28428217
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Sep;1862(9):929-938
pubmed: 28602962
Mol Cell. 2017 Oct 5;68(1):144-157.e5
pubmed: 28965817
Hepatology. 2018 May;67(5):1768-1783
pubmed: 29140550
Nat Med. 2018 Mar;24(3):304-312
pubmed: 29431742
Vascul Pharmacol. 2019 Mar;114:122-130
pubmed: 29548902
Curr Opin Lipidol. 2018 Jun;29(3):224-232
pubmed: 29553997

Auteurs

Elizabeth J Hennessy (EJ)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Coen van Solingen (C)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Kaitlyn R Scacalossi (KR)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Mireille Ouimet (M)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Milessa S Afonso (MS)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Jurrien Prins (J)

Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands.

Graeme J Koelwyn (GJ)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Monika Sharma (M)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Bhama Ramkhelawon (B)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Susan Carpenter (S)

Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, USA.

Albert Busch (A)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.

Ekaterina Chernogubova (E)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Ljubica Perisic Matic (LP)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Ulf Hedin (U)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.

Lars Maegdefessel (L)

Department of Molecular Medicine and Surgery, Karolinska Institute, Stockholm, Sweden.
Department of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.

Brian E Caffrey (BE)

Max Planck Institute for Molecular Genetics, Berlin, Germany.

Maryem A Hussein (MA)

Department of Microbiology, New York University School of Medicine, New York, New York, USA.

Emiliano P Ricci (EP)

INSERM U1111, Centre International de Recherche en Infectiologie, Ecole Normale Supérieure de Lyon, Université de Lyon, Lyon, France.

Ryan E Temel (RE)

Saha Cardiovascular Research Center, University of Kentucky, Lexington, Kentucky, USA.

Michael J Garabedian (MJ)

Department of Microbiology, New York University School of Medicine, New York, New York, USA.

Jeffrey S Berger (JS)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Kasey C Vickers (KC)

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tenessee, USA.

Matthew Kanke (M)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA.

Praveen Sethupathy (P)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University Ithaca, New York, USA.

Daniel Teupser (D)

Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

Lesca M Holdt (LM)

Institute of Laboratory Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

Kathryn J Moore (KJ)

Department of Medicine, Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Artériopathies oblitérantes › Artériosclérose › Athérosclérose › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs hépatiques X › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › The long noncoding RNA CHROME regulates...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › The long noncoding RNA CHROME regulates...