Multimodality imaging and genomics of granulosa cell tumors.
Granulosa cell tumor
Ovarian neoplasms
Ovary
Sex cord-gonadal stromal tumors
Journal
Abdominal radiology (New York)
ISSN: 2366-0058
Titre abrégé: Abdom Radiol (NY)
Pays: United States
ID NLM: 101674571
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
pubmed:
15
8
2019
medline:
10
3
2021
entrez:
15
8
2019
Statut:
ppublish
Résumé
The purpose of this article is to review the imaging findings and genomics of granulosa cell tumors (GCTs) in order to aid in diagnosis and management of GCTs. GCTs are the most common type of sex cord-stromal tumors of the ovary. They are usually diagnosed initially with ultrasound and are subsequently further characterized with CT and MRI. PET/CT is often ordered as well to measure the extent of disease and for follow-up, but its usefulness is in question as some GCTs lack FDG avidity. There is significant variability in imaging phenotypes of GCTs, ranging from mostly cystic to almost solid. More resources have recently been dedicated to understanding the genetics and molecular mechanisms of GCT development. Current research shows that the main cause of GCT carcinogenesis is the FOXL2 mutation, but there are several other noteworthy mutations that contribute to the pathogenesis of this disease. Certain mutations, like GATA4, are known to be associated with more aggressive disease and higher rates of recurrence. Using this information, imaging protocols can be altered depending on the genotype of the tumor. Further understanding of the genetic alterations that underpin the development of GCTs is indicated as genotypic knowledge could be used to guide optimal imaging and management strategies.
Identifiants
pubmed: 31410505
doi: 10.1007/s00261-019-02172-3
pii: 10.1007/s00261-019-02172-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
812-827Références
Young RH (2005) Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 18(Suppl 2):81. https://doi.org/10.1038/modpathol.3800311
doi: 10.1038/modpathol.3800311
Lack EE, Perez-Atayde AR, Murthy AS, Goldstein DP, Crigler JF, Vawter GF (1981) Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases. Cancer 48 (8):1846–1854
doi: 10.1002/1097-0142(19811015)48:8<1846::AID-CNCR2820480823>3.0.CO;2-T
Zhang H, Zhang H, Gu S, Zhang Y, Liu X, Zhang G (2018) MR findings of primary ovarian granulosa cell tumor with focus on the differentiation with other ovarian sex cord-stromal tumors. J Ovarian Res 11 (1):46. https://doi.org/10.1186/s13048-018-0416-x
doi: 10.1186/s13048-018-0416-x
pubmed: 29871662
pmcid: 5989475
Li J, Bao R, Peng S, Zhang C (2018) The molecular mechanism of ovarian granulosa cell tumors. Journal of Ovarian Research 11 (13)
Thomakos N, Biliatis I, Koutroumpa I, Sotiropoulou M, Bamias A, Liontos M, Vlachos G, Rodolakis A (2016) Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. Arch Gynecol Obstet 294 (5):1031–1036. https://doi.org/10.1007/s00404-016-4135-5
doi: 10.1007/s00404-016-4135-5
pubmed: 27324782
Inada Y, Nakai G, Yamamoto K, Yamada T, Hirose Y, Terai Y, Ohmichi M, Narumi Y (2018) Rapidly growing juvenile granulosa cell tumor of the ovary arising in adult: a case report and review of the literature. J Ovarian Res 11 (1):100. https://doi.org/10.1186/s13048-018-0474-0
doi: 10.1186/s13048-018-0474-0
pubmed: 30547828
pmcid: 6293549
Elbachiri M, Taleb A, Derrabi N, Bouchbika Z, Benchakroun N, Jouhadi H, Tawfiq N, Sahraoui S, Benider A (2017) Adult-type granulosa cell tumor of the testis: report of a case and review of literature. Pan Afr Med J 26:198. https://doi.org/10.11604/pamj.2017.26.198.11523
doi: 10.11604/pamj.2017.26.198.11523
pubmed: 28674591
pmcid: 5483374
Boyce EA, Costaggini I, Vitonis A, Feltmate C, Muto M, Berkowitz R, Cramer D, Horowitz NS (2009) The epidemiology of ovarian granulosa cell tumors: a case-control study. Gynecol Oncol 115 (2):221–225. https://doi.org/10.1016/j.ygyno.2009.06.040
doi: 10.1016/j.ygyno.2009.06.040
pubmed: 19664811
Skinner MK, Schmidt M, Savenkova MI, Sadler-Riggleman I, Nilsson EE (2008) Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development. Mol Reprod Dev 75 (9):1457-1472. https://doi.org/10.1002/mrd.20883
doi: 10.1002/mrd.20883
pubmed: 18288646
pmcid: 5749411
Stein M, Koenigsberg M, Han M (1996) US case of the day. Adult-type granulosa cell tumor. Radiographics 16 (1):200-203. https://doi.org/10.1148/radiographics.16.1.200
doi: 10.1148/radiographics.16.1.200
pubmed: 10946701
Ko SF, Wan YL, Ng SH, Lee TY, Lin JW, Chen WJ, Kung FT, Tsai CC (1999) Adult ovarian granulosa cell tumors: spectrum of sonographic and CT findings with pathologic correlation. AJR Am J Roentgenol 172 (5):1227–1233. https://doi.org/10.2214/ajr.172.5.10227493
doi: 10.2214/ajr.172.5.10227493
pubmed: 10227493
Kim JH, Yoon S, Park M, Park HO, Ko JJ, Lee K, Bae J (2011) Differential apoptotic activities of wild-type FOXL2 and the adult-type granulosa cell tumor-associated mutant FOXL2 (C134 W). Oncogene 30 (14):1653–1663. https://doi.org/10.1038/onc.2010.541
doi: 10.1038/onc.2010.541
pubmed: 21119601
Suh D-S, Oh HK, Kim J-H, Park S, Shin E, Lee K, Kim Y-H, Bae J (2015) Identification and Validation of Differential Phosphorylation Sites of the Nuclear FOXL2 Protein as Potential Novel Biomarkers for Adult-Type Granulosa Cell Tumors. J Proteome Res 14 (6):2446–2456. https://doi.org/10.1021/pr501230b
doi: 10.1021/pr501230b
pubmed: 25871347
Leung DTH, Fuller PJ, Chu S (2016) Impact of FOXL2 mutations on signaling in ovarian granulosa cell tumors. Int J Biochem Cell Biol 72:51-54. https://doi.org/10.1016/j.biocel.2016.01.003
doi: 10.1016/j.biocel.2016.01.003
pubmed: 26791928
Jamieson S, Fuller PJ (2012) Molecular pathogenesis of granulosa cell tumors of the ovary. Endocr Rev 33 (1):109–144. https://doi.org/10.1210/er.2011-0014
doi: 10.1210/er.2011-0014
pubmed: 22240241
Fuller PJ, Leung D, Chu S (2017) Genetics and genomics of ovarian sex cord-stromal tumors. Clin Genet 91 (2):285–291. https://doi.org/10.1111/cge.12917
doi: 10.1111/cge.12917
pubmed: 27813081
Farkkila A, Haltia UM, Tapper J, McConechy MK, Huntsman DG, Heikinheimo M (2017) Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. Ann Med 49 (5):435–447. https://doi.org/10.1080/07853890.2017.1294760
doi: 10.1080/07853890.2017.1294760
pubmed: 28276867
Anttonen M, Unkila-Kallio L, Leminen A, Butzow R, Heikinheimo M (2005) High GATA-4 expression associates with aggressive behavior, whereas low anti-Müllerian hormone expression associates with growth potential of ovarian granulosa cell tumors. The Journal of Clinical Endocrinology and Metabolism 90 (12):6529–6535. https://doi.org/10.1210/jc.2005-0921
doi: 10.1210/jc.2005-0921
pubmed: 16159935
Färkkilä A, Pihlajoki M, Tauriala H, Bützow R, Leminen A, Unkila-Kallio L, Heikinheimo M, Anttonen M (2011) Serum vascular endothelial growth factor A (VEGF) is elevated in patients with ovarian granulosa cell tumor (GCT), and VEGF inhibition by bevacizumab induces apoptosis in GCT in vitro. The Journal of Clinical Endocrinology and Metabolism 96 (12):1973. https://doi.org/10.1210/jc.2011-1812
doi: 10.1210/jc.2011-1812
Chang HL, Pahlavan N, Halpern EF, MacLaughlin DT (2009) Serum Müllerian Inhibiting Substance/anti-Müllerian hormone levels in patients with adult granulosa cell tumors directly correlate with aggregate tumor mass as determined by pathology or radiology. Gynecol Oncol 114 (1):57–60. https://doi.org/10.1016/j.ygyno.2009.02.023
doi: 10.1016/j.ygyno.2009.02.023
pubmed: 19359032
pmcid: 2756071
Kalfa N, Veitia RA, Benayoun BA, Boizet-Bonhoure B, Sultan C (2009) The new molecular biology of granulosa cell tumors of the ovary. Genome Med 1 (8):81. https://doi.org/10.1186/gm81
doi: 10.1186/gm81
pubmed: 19725933
pmcid: 2768967
Tsoi M, Laguë M-N, Boyer A, Paquet M, Nadeau M-È, Boerboom D (2013) Anti-VEGFA Therapy Reduces Tumor Growth and Extends Survival in a Murine Model of Ovarian Granulosa Cell Tumor. Transl Oncol 6 (3):226–233
doi: 10.1593/tlo.13136
Dridi M, Chraiet N, Batti R, Ayadi M, Mokrani A, Meddeb K, Yahiaoui Y, Raies H, Mezlini A (2018) Granulosa Cell Tumor of the Ovary: A Retrospective Study of 31 Cases and a Review of the Literature. Int J Surg Oncol 2018:4547892. https://doi.org/10.1155/2018/4547892
doi: 10.1155/2018/4547892
pubmed: 29796312
pmcid: 5896205
Khosla D, Dimri K, Pandey AK, Mahajan R, Trehan R (2014) Ovarian Granulosa Cell Tumor: Clinical Features, Treatment, Outcome, and Prognostic Factors. N Am J Med Sci 6 (3):133–138. https://doi.org/10.4103/1947-2714.128475
doi: 10.4103/1947-2714.128475
pubmed: 24741552
pmcid: 3978936
Evans AT, Gaffey TA, Malkasian GD, Annegers JF (1980) Clinicopathologic review of 118 granulosa and 82 theca cell tumors. Obstet Gynecol 55 (2):231–238
pubmed: 6243409
Lappöhn RE, Burger HG, Bouma J, Bangah M, Krans M, de Bruijn HW (1989) Inhibin as a marker for granulosa-cell tumors. The New England Journal of Medicine 321 (12):790–793. https://doi.org/10.1056/nejm198909213211204
doi: 10.1056/NEJM198909213211204
pubmed: 2770810
Mom CH, Engelen MJA, Willemse PHB, Gietema JA, ten Hoor KA, de Vries EGE, van der Zee AGJ (2007) Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 105 (2):365–372. https://doi.org/10.1016/j.ygyno.2006.12.034
doi: 10.1016/j.ygyno.2006.12.034
pubmed: 17306349
Kottarathil VD, Antony MA, Nair IR, Pavithran K (2013) Recent advances in granulosa cell tumor ovary: a review. Indian journal of surgical oncology 4 (1):37–47. https://doi.org/10.1007/s13193-012-0201-z
doi: 10.1007/s13193-012-0201-z
pubmed: 24426698
Färkkilä A, Koskela S, Bryk S, Alfthan H, Bützow R, Leminen A, Puistola U, Tapanainen JS, Heikinheimo M, Anttonen M, Unkila-Kallio L (2015) The clinical utility of serum anti-Müllerian hormone in the follow-up of ovarian adult-type granulosa cell tumors–A comparative study with inhibin B. Int J Cancer 137 (7):1661–1671. https://doi.org/10.1002/ijc.29532
doi: 10.1002/ijc.29532
pubmed: 25808251
Levin G, Zigron R, Haj-Yahya R, Matan LS, Rottenstreich A (2018) Granulosa cell tumor of ovary: A systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol 225:57–61. https://doi.org/10.1016/j.ejogrb.2018.04.002
doi: 10.1016/j.ejogrb.2018.04.002
pubmed: 29665458
Seung Eun J, Jae Mun L, Sung Eun R, Jae Young B, Jung Im J, Seong Tai H (2002) CT and MR Imaging of Ovarian Tumors with Emphasis on Differential Diagnosis1. Radiographics 22 (6):1305. https://doi.org/10.1148/rg.226025033
doi: 10.1148/rg.226025033
Jung SE, Rha SE, Lee JM, Park SY, Oh SN, Cho KS, Lee EJ, Byun JY, Hahn ST (2005) CT and MRI Findings of Sex Cord-Stromal Tumor of the Ovary. AJR Am J Roentgenol 185 (1):207-215. https://doi.org/10.2214/ajr.185.1.01850207
doi: 10.2214/ajr.185.1.01850207
pubmed: 15972425
Kim SH, Kim SH (2002) Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. J Comput Assist Tomogr 26 (5):756–761
doi: 10.1097/00004728-200209000-00016
Iyer VR, Lee SI (2010) MRI, CT, and PET/CT for Ovarian Cancer Detection and Adnexal Lesion Characterization. AJR Am J Roentgenol 194 (2):311–321. https://doi.org/10.2214/ajr.09.3522
doi: 10.2214/AJR.09.3522
pubmed: 20093590
Mansour GM, El-Lamie IK, El-Sayed HM, Ibrahim AM, Laban M, Abou-Louz SK, Abd Allah MY, El-Mahallawi MN, El-Lamie KI, Gad-Allah M (2009) Adnexal mass vascularity assessed by 3-dimensional power Doppler: does it add to the risk of malignancy index in prediction of ovarian malignancy?: four hundred-case study. Int J Gynecol Cancer 19 (5):867–872. https://doi.org/10.1111/igc.0b013e3181a8335e
doi: 10.1111/IGC.0b013e3181a8335e
pubmed: 19574775
Kinkel K, Lu Y, Mehdizade A, Pelte M-F, Hricak H (2005) Indeterminate Ovarian Mass at US: Incremental Value of Second Imaging Test for Characterization—Meta-Analysis and Bayesian Analysis. Radiology 236 (1):85–94. https://doi.org/10.1148/radiol.2361041618
doi: 10.1148/radiol.2361041618
pubmed: 15955864
Adusumilli S, Hussain HK, Caoili EM, Weadock WJ, Murray JP, Johnson TD, Chen Q, Desjardins B (2006) MRI of Sonographically Indeterminate Adnexal Masses. AJR Am J Roentgenol 187 (3):732–740. https://doi.org/10.2214/ajr.05.0905
doi: 10.2214/AJR.05.0905
pubmed: 16928938
Inoue C, Fujii S, Nosaka K, Mukuda N, Fukunaga T, Ogawa T (2018) A Small Granulosa Cell Tumor of the Ovary Incidentally Detected on Diffusion-weighted Images. Magn Reson Med Sci. https://doi.org/10.2463/mrms.ci.2018-0033
doi: 10.2463/mrms.ci.2018-0033
Morikawa K, Hatabu H, Togashi K, Kataoka ML, Mori T, Konishi J (1997) Granulosa cell tumor of the ovary: MR findings. J Comput Assist Tomogr 21 (6):1001–1004
doi: 10.1097/00004728-199711000-00028
Thomassin-Naggara I, Aubert E, Rockall A, Jalaguier-Coudray A, Rouzier R, Darai E, Bazot M (2013) Adnexal masses: development and preliminary validation of an MR imaging scoring system. Radiology 267 (2):432–443. https://doi.org/10.1148/radiol.13121161
doi: 10.1148/radiol.13121161
pubmed: 23468574
Pereira PN, Sarian LO, Yoshida A, Araújo KG, Barros RH, Baião AC, Parente DB, Derchain S (2018) Accuracy of the ADNEX MR scoring system based on a simplified MRI protocol for the assessment of adnexal masses. Diagn Interv Radiol 24 (2):63
pubmed: 29467113
pmcid: 5873504
Gunyeli I, Bozkurt KK, Yalcin Y, Tatar B, Cerci SS, Erdemoglu E (2014) Granulosa cell tumor and concurrent endometrial cancer with (18)F-FDG uptake. Hell J Nucl Med 17 (2):153-155
pubmed: 25097899
Horny HP, Marx L, Krober S, Luttges J, Kaiserling E, Dietl J (1999) Granulosa cell tumor of the ovary. Immunohistochemical evidence of low proliferative activity and virtual absence of mutation of the p53 tumor-suppressor gene. Gynecol Obstet Invest 47 (2):133–138. https://doi.org/10.1159/000010077
doi: 10.1159/000010077
Caoduro C, Ungureanu CM, Singeorzan CM, Angoue O, Blagosklonov O, Boulahdour H (2013) Granulosa cell tumor of the ovary with high FDG uptake. Clin Nucl Med 38 (7):553–556. https://doi.org/10.1097/rlu.0b013e318292aa65
doi: 10.1097/RLU.0b013e318292aa65
pubmed: 23640219
Tanizaki Y, Kobayashi A, Shiro M, Ota N, Takano R, Mabuchi Y, Yagi S, Minami S, Terada M, Ino K (2014) Diagnostic value of preoperative SUVmax on FDG-PET/CT for the detection of ovarian cancer. Int J Gynecol Cancer 24 (3):454–460. https://doi.org/10.1097/igc.0000000000000074
doi: 10.1097/igc.0000000000000074
pubmed: 24463640
Miller BE, Barron BA, Wan JY, Delmore JE, Silva EG, Gershenson DM (1997) Prognostic factors in adult granulosa cell tumor of the ovary. Cancer 79 (10):1951–1955
doi: 10.1002/(SICI)1097-0142(19970515)79:10<1951::AID-CNCR16>3.0.CO;2-U
Mutch DG, Prat J (2014) 2014 FIGO staging for ovarian, fallopian tube and peritoneal cancer. Gynecol Oncol 133 (3):401–404. https://doi.org/10.1016/j.ygyno.2014.04.013
doi: 10.1016/j.ygyno.2014.04.013
pubmed: 24878391
Berek JS, Kehoe ST, Kumar L, Friedlander M (2018) Cancer of the ovary, fallopian tube, and peritoneum. Int J Gynaecol Obstet 143 Suppl 2:59–78. https://doi.org/10.1002/ijgo.12614
doi: 10.1002/ijgo.12614
pubmed: 30306591
Pankratz E, Boyes DA, White GW, Galliford BW, Fairey RN, Benedet JL (1978) Granulosa cell tumors. A clinical review of 61 cases. Obstet Gynecol 52 (6):718–723
pubmed: 733139
Schumer ST, Cannistra SA (2003) Granulosa cell tumor of the ovary. J Clin Oncol 21 (6):1180-1189. https://doi.org/10.1200/jco.2003.10.019
doi: 10.1200/JCO.2003.10.019
pubmed: 12637488
Chan JK, Zhang M, Kaleb V, Loizzi V, Benjamin J, Vasilev S, Osann K, Disaia PJ (2005) Prognostic factors responsible for survival in sex cord stromal tumors of the ovary–a multivariate analysis. Gynecol Oncol 96 (1):204-209. https://doi.org/10.1016/j.ygyno.2004.09.019
doi: 10.1016/j.ygyno.2004.09.019
pubmed: 15589602
Zhang M, Cheung MK, Shin JY, Kapp DS, Husain A, Teng NN, Berek JS, Osann K, Chan JK (2007) Prognostic factors responsible for survival in sex cord stromal tumors of the ovary–an analysis of 376 women. Gynecol Oncol 104 (2):396–400. https://doi.org/10.1016/j.ygyno.2006.08.032
doi: 10.1016/j.ygyno.2006.08.032
pubmed: 17030354
Seagle BL, Ann P, Butler S, Shahabi S (2017) Ovarian granulosa cell tumor: A National Cancer Database study. Gynecol Oncol 146 (2):285-291. https://doi.org/10.1016/j.ygyno.2017.05.020
doi: 10.1016/j.ygyno.2017.05.020
pubmed: 28532858
Zhao SH, Li HM, Qiang JW, Wang DB, Fan H (2018) The value of MRI for differentiating benign from malignant sex cord-stromal tumors of the ovary: emphasis on diffusion-weighted MR imaging. J Ovarian Res 11 (1):73. https://doi.org/10.1186/s13048-018-0444-6
doi: 10.1186/s13048-018-0444-6
pubmed: 30165895
pmcid: 6116557
Shinagare AB, Meylaerts LJ, Laury AR, Mortele KJ (2012) MRI features of ovarian fibroma and fibrothecoma with histopathologic correlation. AJR Am J Roentgenol 198 (3):W296–W303. https://doi.org/10.2214/ajr.11.7221
doi: 10.2214/AJR.11.7221
pubmed: 22358029
Kobayashi E, Yokoyama T, Nakagawa S, Matsuzaki S, Kimura T, Ueda YJGO (2013) Pedunculated sub-serous leiomyosarcoma mimicking ovarian cancer: case report and review of literature. 3 (157):2161–0932.1000157
Lee JH, Jeong YK, Park JK, Hwang JC (2003) “Ovarian vascular pedicle” sign revealing organ of origin of a pelvic mass lesion on helical CT. AJR Am J Roentgenol 181 (1):131–137
doi: 10.2214/ajr.181.1.1810131
Gershenson DM (1994) Management of early ovarian cancer: germ cell and sex cord-stromal tumors. Gynecol Oncol 55 (3 Pt 2):62
van Meurs HS, Bleeker MC, van der Velden J, Overbeek LI, Kenter GG, Buist MR (2013) The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. Int J Gynecol Cancer 23 (8):1417–1422. https://doi.org/10.1097/igc.0b013e3182a57fb4
doi: 10.1097/IGC.0b013e3182a57fb4
pubmed: 24257556
Iavazzo C, Gkegkes ID, Vrachnis N (2015) Fertility sparing management and pregnancy in patients with granulosa cell tumour of the ovaries. J Obstet Gynaecol 35 (4):331–335. https://doi.org/10.3109/01443615.2014.968107
doi: 10.3109/01443615.2014.968107
pubmed: 25383508
Uygun K, Aydiner A, Saip P, Kocak Z, Basaran M, Dincer M, Topuz E (2003) Clinical parameters and treatment results in recurrent granulosa cell tumor of the ovary. Gynecol Oncol 88 (3):400-403
doi: 10.1016/S0090-8258(02)00141-5
Zanagnolo V, Pasinetti B, Sartori E (2004) Clinical review of 63 cases of sex cord stromal tumors. Eur J Gynaecol Oncol 25 (4):431–438
pubmed: 15285297
Sonoyama A, Kanda M, Ojima Y, Kizaki T, Ohara N (2016) Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. Kobe J Med Sci 61 (4):E109–114
Hauspy J, Beiner ME, Harley I, Rosen B, Murphy J, Chapman W, Le LW, Fyles A, Levin W (2011) Role of adjuvant radiotherapy in granulosa cell tumors of the ovary. Int J Radiat Oncol Biol Phys 79 (3):770–774. https://doi.org/10.1016/j.ijrobp.2009.12.005
doi: 10.1016/j.ijrobp.2009.12.005
pubmed: 20472362
Mangili G, Ottolina J, Gadducci A, Giorda G, Breda E, Savarese A, Candiani M, Frigerio L, Scarfone G, Pignata S, Rossi R, Marinaccio M, Lorusso D (2013) Long-term follow-up is crucial after treatment for granulosa cell tumours of the ovary. Br J Cancer 109 (1):29–34. https://doi.org/10.1038/bjc.2013.241
doi: 10.1038/bjc.2013.241
pubmed: 23756859
pmcid: 3708585
Stuart GC, Dawson LM (2003) Update on granulosa cell tumours of the ovary. Curr Opin Obstet Gynecol 15 (1):33–37. https://doi.org/10.1097/01.gco.0000051557.77832.1b
doi: 10.1097/01.gco.0000051557.77832.1b
pubmed: 12544499
Salani R, Khanna N, Frimer M, Bristow RE, Chen LM (2017) An update on post-treatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncology (SGO) recommendations. Gynecol Oncol 146 (1):3–10. https://doi.org/10.1016/j.ygyno.2017.03.022
doi: 10.1016/j.ygyno.2017.03.022
pubmed: 28372871
Doubeni CA, Doubeni AR, Myers AE (2016) Diagnosis and Management of Ovarian Cancer. Am Fam Physician 93 (11):937–944
pubmed: 27281838
Ray-Coquard I, Brown J, Harter P, Provencher DM, Fong PC, Maenpaa J, Ledermann JA, Emons G, Rigaud DB, Glasspool RM, Mezzanzanica D, Colombo N (2014) Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian sex cord stromal tumors. Int J Gynecol Cancer 24 (9 Suppl 3):S42–47. https://doi.org/10.1097/igc.0000000000000249
doi: 10.1097/igc.0000000000000249
pubmed: 25341579
Thrall MM, DeLoia JA, Gallion H, Avril N (2007) Clinical use of combined positron emission tomography and computed tomography (FDG-PET/CT) in recurrent ovarian cancer. Gynecol Oncol 105 (1):17–22. https://doi.org/10.1016/j.ygyno.2006.10.060
doi: 10.1016/j.ygyno.2006.10.060
pubmed: 17208284
Raj G, Proietto A, Jaaback K (2009) Positron emission tomography and granulosa cell tumor recurrence: a report of 2 cases. Int J Gynecol Cancer 19 (9):1542–1544. https://doi.org/10.1111/igc.0b013e3181a84819
doi: 10.1111/IGC.0b013e3181a84819
pubmed: 19955934
Huang YT, Lee JC, Kumar ASR (2009) Variable F-18 fluorodeoxyglucose avidity of metastatic recurrent adult granulosa cell tumor. Clin Nucl Med 34 (10):710-712. https://doi.org/10.1097/rlu.0b013e3181b539e4
doi: 10.1097/RLU.0b013e3181b539e4
pubmed: 19893410
Manganaro L, Gigli S, Antonelli A, Saldari M, Tomao F, Marchetti C, Anastasi E, Laghi A (2018) Imaging strategy in recurrent ovarian cancer: a practical review. Abdom Radiol (NY). https://doi.org/10.1007/s00261-018-1677-y
doi: 10.1007/s00261-018-1677-y
Sohaib SAA, Reznek RH (2007) MR imaging in ovarian cancer. Cancer imaging: the official publication of the International Cancer Imaging Society 7 Spec No A (Special issue A):S119–S129. https://doi.org/10.1102/1470-7330.2007.9046
doi: 10.1102/1470-7330.2007.9046
Low RN, Barone RM, Lucero J (2015) Comparison of MRI and CT for predicting the Peritoneal Cancer Index (PCI) preoperatively in patients being considered for cytoreductive surgical procedures. Ann Surg Oncol 22 (5):1708-1715
doi: 10.1245/s10434-014-4041-7