Current status of umbilical cord blood transplantation in children.
Cord blood transplantation
children
engraftment
graft-versus-host disease
stem cell transplantation
Journal
British journal of haematology
ISSN: 1365-2141
Titre abrégé: Br J Haematol
Pays: England
ID NLM: 0372544
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
11
04
2019
revised:
19
06
2019
accepted:
19
06
2019
pubmed:
15
8
2019
medline:
10
3
2021
entrez:
15
8
2019
Statut:
ppublish
Résumé
The first umbilical cord blood (UCB) transplantation was performed 30 years ago. UCB transplantation (UCBT) is now widely used in children with malignant and non-malignant disorders who lack a matched family donor. UCBT affords a lower incidence of graft-versus-host disease compared to alternative stem cell sources, but also presents a slower immune recovery and a high risk of infections if serotherapy is not omitted or targeted within the conditioning regimen. The selection of UCB units with high cell content and good human leucocyte antigen match is essential to improve the outcome. Techniques, such as double UCBT, ex vivo stem cell expansion and intra-bone injection of UCB, have improved cord blood engraftment, but clinical benefit remains to be demonstrated. Cell therapies derived from UCB are under evaluation as potential novel strategies to reduce relapse and viral infections following transplantation. In recent years, improvements within haploidentical transplantation have reduced the overall use of UCBT as an alternative stem cell source; however, each may have its relative merits and disadvantages and tailored use of these alternative stem cell sources may be the optimal approach.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
650-683Informations de copyright
© 2019 British Society for Haematology and John Wiley & Sons Ltd.
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