Plasma ghrelin levels after laparoscopic sleeve gastrectomy in obese individuals.
Ghrelin
obese
sleeve gastrectomy
weight loss
Journal
The Indian journal of medical research
ISSN: 0971-5916
Titre abrégé: Indian J Med Res
Pays: India
ID NLM: 0374701
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
23
1
2020
Statut:
ppublish
Résumé
Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients. The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen. These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.
Sections du résumé
Background & objectives
Ghrelin is an orexigenic gut hormone expressed by the gastric fundus. Laparoscopic sleeve gastrectomy (LSG) procedure involves resection of the gastric fundus leading to a decreased appetite and weight loss. This study was undertaken to determine the levels of plasma ghrelin after sleeve gastrectomy in obese patients.
Methods
The study was conducted on 90 morbidly obese patients [body mass index (BMI) >40 kg/m
Results
A significant weight loss and decrease in BMI were observed at three and six months postoperatively. A significant decrease in plasma ghrelin levels over six months of follow up postoperatively was also seen.
Interpretation & conclusions
These preliminary findings indicated inhibition of ghrelin production after LSG leading to a decrease in the plasma ghrelin levels within a few days of surgery and sustainable weight loss in obese patients.
Identifiants
pubmed: 31411179
pii: IndianJMedRes_2019_149_4_544_262888
doi: 10.4103/ijmr.IJMR_984_18
pmc: PMC6676842
doi:
Substances chimiques
Biomarkers
0
Ghrelin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
544-547Déclaration de conflit d'intérêts
None
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