Neurite outgrowth in symptomatic uncomplicated diverticular disease.
Journal
Neurogastroenterology and motility
ISSN: 1365-2982
Titre abrégé: Neurogastroenterol Motil
Pays: England
ID NLM: 9432572
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
18
05
2019
revised:
30
06
2019
accepted:
02
07
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
25
8
2020
Statut:
ppublish
Résumé
Diverticulosis is the presence of small, bulging pouches in the lining of the intestinal colonic mucosal and submucosal layers. This condition is usually asymptomatic. The few patients (25%) that do develop abdominal symptoms are diagnosed with symptomatic uncomplicated diverticular disease (SUDD). Up to now it is not clear which pathophysiological events trigger the transition from asymptomatic diverticulosis to SUDD. However, data from Barbaro and colleagues published in the current issue of Neurogastroenterology and Motility showed extensive axonal sprouting and increased macrophage infiltration in SUDD compared to asymptomatic diverticulosis patients. Thereby they provide more evidence suggesting that enteric neuro-plasticity, whether or not affected by infiltrating macrophages, may underlie the development of symptoms in diverticulosis.
Substances chimiques
Neuropeptides
0
Types de publication
Editorial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13680Informations de copyright
© 2019 John Wiley & Sons Ltd.
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