Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers.
Animals
Animals, Newborn
Antibodies
/ blood
Antibodies, Viral
/ blood
Antibody Formation
/ immunology
B-Lymphocytes
/ immunology
Female
Germinal Center
/ immunology
Immunization
Male
Maternal-Fetal Exchange
/ immunology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Orthomyxoviridae
/ immunology
Orthomyxoviridae Infections
/ immunology
Pregnancy
T-Lymphocytes, Helper-Inducer
/ immunology
Vaccination
epitope masking
germinal centers
immunization
maternal antibodies
neonates
repertoire
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
13 08 2019
13 08 2019
Historique:
received:
05
03
2019
revised:
01
07
2019
accepted:
15
07
2019
entrez:
15
8
2019
pubmed:
15
8
2019
medline:
5
9
2020
Statut:
ppublish
Résumé
Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different V
Identifiants
pubmed: 31412246
pii: S2211-1247(19)30951-9
doi: 10.1016/j.celrep.2019.07.047
pii:
doi:
Substances chimiques
Antibodies
0
Antibodies, Viral
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1773-1784.e5Informations de copyright
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.