Genetic induction and mechanochemical propagation of a morphogenetic wave.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
28
09
2018
accepted:
10
07
2019
pubmed:
16
8
2019
medline:
27
3
2020
entrez:
16
8
2019
Statut:
ppublish
Résumé
Tissue morphogenesis arises from coordinated changes in cell shape driven by actomyosin contractions. Patterns of gene expression regionalize cell behaviours by controlling actomyosin contractility. Here we report two modes of control over Rho1 and myosin II (MyoII) activation in the Drosophila endoderm. First, Rho1-MyoII are induced in a spatially restricted primordium via localized transcription of the G-protein-coupled receptor ligand Fog. Second, a tissue-scale wave of Rho1-MyoII activation and cell invagination progresses anteriorly away from the primordium. The wave does not require sustained gene transcription, and is not governed by regulated Fog delivery. Instead, MyoII inhibition blocks Rho1 activation and propagation, revealing a mechanical feedback driven by MyoII. We find that MyoII activation and invagination in each row of cells drives adhesion to the vitelline membrane mediated by integrins, apical spreading, MyoII activation and invagination in the next row. Endoderm morphogenesis thus emerges from local transcriptional initiation and a mechanically driven cycle of cell deformation.
Identifiants
pubmed: 31413363
doi: 10.1038/s41586-019-1492-9
pii: 10.1038/s41586-019-1492-9
pmc: PMC8985608
mid: NIHMS1620917
doi:
Substances chimiques
Drosophila Proteins
0
Integrins
0
Myosin Type II
EC 3.6.1.-
Rho1 protein, Drosophila
EC 3.6.5.2
rho GTP-Binding Proteins
EC 3.6.5.2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
467-473Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM098441
Pays : United States
Organisme : NIGMS NIH HHS
ID : 1R01 GM098441-06
Pays : United States
Commentaires et corrections
Type : CommentIn
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