Niche stiffness underlies the ageing of central nervous system progenitor cells.

Adult Stem Cells / pathology Aging / pathology Animals Animals, Newborn Cell Count Central Nervous System / pathology Extracellular Matrix / pathology Female Humans Membrane Proteins / antagonists & inhibitors Multipotent Stem Cells / pathology Oligodendroglia / pathology Rats Stem Cell Niche / physiology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2019
Historique:
received: 07 04 2017
accepted: 15 07 2019
pubmed: 16 8 2019
medline: 31 3 2020
entrez: 16 8 2019
Statut: ppublish

Résumé

Ageing causes a decline in tissue regeneration owing to a loss of function of adult stem cell and progenitor cell populations

Identifiants

DOI: 10.1038/s41586-019-1484-9 PMID: 31413369 PMC: PMC7025879
pubmed: 31413369
doi: 10.1038/s41586-019-1484-9
pii: 10.1038/s41586-019-1484-9
pmc: PMC7025879
mid: EMS83737
doi:

Substances chimiques

Membrane Proteins 0
Piezo1 protein, rat 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

130-134

Subventions

Organisme : Medical Research Council
ID : MR/M011089/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_12009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K017047/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N006402/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1002/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 203151
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R015635/1
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Michael Segel (M)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Björn Neumann (B)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Myfanwy F E Hill (MFE)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Isabell P Weber (IP)

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Carlo Viscomi (C)

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

Chao Zhao (C)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Adam Young (A)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Chibeza C Agley (CC)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

Amelia J Thompson (AJ)

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Ginez A Gonzalez (GA)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Amar Sharma (A)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Staffan Holmqvist (S)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

David H Rowitch (DH)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Paediatrics, University of Cambridge, Cambridge, UK.

Kristian Franze (K)

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.

Robin J M Franklin (RJM)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. rjf1000@cam.ac.uk.
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. rjf1000@cam.ac.uk.

Kevin J Chalut (KJ)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. kc370@cam.ac.uk.
Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK. kc370@cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules souches › Cellules souches adultes › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Eucaryotes › Animaux › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Numération cellulaire › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Matrice extracellulaire › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Cellules › Névroglie › Oligodendroglie › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Niche stiffness underlies the ageing of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Niche de cellules souches › Niche stiffness underlies the ageing of...