CYRI/ Fam49 Proteins Represent a New Class of Rac1 Interactors.
GTPase signaling
Rac1
actin
cancer invasion
cell migration
Journal
Communicative & integrative biology
ISSN: 1942-0889
Titre abrégé: Commun Integr Biol
Pays: United States
ID NLM: 101478473
Informations de publication
Date de publication:
2019
2019
Historique:
received:
23
05
2019
revised:
01
07
2019
accepted:
02
07
2019
entrez:
16
8
2019
pubmed:
16
8
2019
medline:
16
8
2019
Statut:
epublish
Résumé
Fam49 proteins, now referred to as CYRI (CYFIP-related Rac Interactor), are evolutionarily conserved across many phyla. Their closest relative by amino acid sequence is CYFIP, as both proteins contain a domain of unknown function DUF1394. We recently showed that CYRI and the DUF1394 can mediate binding to Rac1 and evidence is building to suggest that CYRI plays important roles in cell migration, chemotaxis and pathogen entry into cells. Here we discuss how CYRI proteins fit into the current framework of the control of actin dynamics by positive and negative feedback loops containing Rac1, the Scar/WAVE Complex, the Arp2/3 Complex and branched actin. We also provide data regarding the interaction between Rac1 and CYRI in an unbiassed mass spectrometry screen for interactors of an active mutant of Rac1.
Identifiants
pubmed: 31413787
doi: 10.1080/19420889.2019.1643665
pii: 1643665
pmc: PMC6682259
doi:
Types de publication
Journal Article
Langues
eng
Pagination
112-118Subventions
Organisme : Medical Research Council
ID : MR/R017255/1
Pays : United Kingdom
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