Plasma CXCL10 correlates with HAND in HIV-infected women.
CXCL-10
HIV inflammation
HIV women
Neurocognitive
Young adults
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
04
03
2019
accepted:
10
07
2019
revised:
22
06
2019
pubmed:
16
8
2019
medline:
15
5
2021
entrez:
16
8
2019
Statut:
ppublish
Résumé
HIV-associated neurocognitive disorder (HAND) is characterized by chronic immune activation. We aimed to identify biomarkers associated with HAND and to investigate their association with cognitive function and sex, in a homogenous cohort of HIV-infected (HIV+) young adults, parenterally infected during early childhood. One hundred forty-four HIV+ Romanian participants (51% women) without major confounders underwent standardized neurocognitive and medical evaluation in a cross-sectional study. IFN-γ, IL-1β, IL-6, CCL2, CXCL8, CXCL10, and TNF-α were measured in plasma in all participants and in cerebrospinal fluid (CSF) in a subgroup of 56 study participants. Biomarkers were compared with neurocognitive outcomes, and the influence of sex and HIV disease biomarkers was assessed. In this cohort of young adults (median age of 24 years), the rate of neurocognitive impairment (NCI) was 36.1%. Median current CD4+ count was 479 cells/mm
Identifiants
pubmed: 31414350
doi: 10.1007/s13365-019-00785-4
pii: 10.1007/s13365-019-00785-4
pmc: PMC7018596
mid: NIHMS1537530
doi:
Substances chimiques
Biomarkers
0
CXCL10 protein, human
0
Chemokine CXCL10
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-31Subventions
Organisme : NIMH NIH HHS
ID : R01 MH105319
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH094159
Pays : United States
Organisme : NIMH NIH HHS
ID : P30 MH062512
Pays : United States
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