Serious immune-related adverse events in patients with head and neck cancer after checkpoint blockade: Systematic review.
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
27
02
2019
revised:
19
06
2019
accepted:
30
07
2019
pubmed:
16
8
2019
medline:
21
11
2020
entrez:
16
8
2019
Statut:
ppublish
Résumé
Immune checkpoint inhibitors confer significant clinical benefit by bolstering immune-system activity, however, they also produce a spectrum of immune-related adverse events (irAEs). Rapid recognition and timely treatment of these patients is essential for improved outcomes. We conducted a systematic review of English-language articles in MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane CENTRAL databases on patients with head and neck cancer treated with immune checkpoint inhibitors who developed treatment-related adverse events. Of 1715 unique citations, 11 studies met inclusion criteria. Eight patients with serious irAEs were reported from case reports and case series. Overall, 46 treatment-related AEs were identified from the pooled 791 patients with at least 12 having potential relevance to irAEs. The most frequent AEs observed in patients receiving PD-1 inhibitors involved the endocrine, cutaneous, and gastrointestinal systems. Characterizing irAEs in longitudinal studies is needed for developing strategies for their prompt recognition and management.
Sections du résumé
BACKGROUND
Immune checkpoint inhibitors confer significant clinical benefit by bolstering immune-system activity, however, they also produce a spectrum of immune-related adverse events (irAEs). Rapid recognition and timely treatment of these patients is essential for improved outcomes.
METHODS
We conducted a systematic review of English-language articles in MEDLINE, EMBASE, Web of Science, PubMed, and Cochrane CENTRAL databases on patients with head and neck cancer treated with immune checkpoint inhibitors who developed treatment-related adverse events.
RESULTS
Of 1715 unique citations, 11 studies met inclusion criteria. Eight patients with serious irAEs were reported from case reports and case series. Overall, 46 treatment-related AEs were identified from the pooled 791 patients with at least 12 having potential relevance to irAEs. The most frequent AEs observed in patients receiving PD-1 inhibitors involved the endocrine, cutaneous, and gastrointestinal systems.
CONCLUSIONS
Characterizing irAEs in longitudinal studies is needed for developing strategies for their prompt recognition and management.
Substances chimiques
Antineoplastic Agents, Immunological
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4036-4050Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE022891
Pays : United States
Organisme : NIDCR NIH HHS
ID : 1R21DE026837
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE022891
Pays : United States
Organisme : NIDCR NIH HHS
ID : 1R21DE026837
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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