Is atopic sensitization associated with indicators of early vascular ageing in adolescents?
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
03
2019
accepted:
10
07
2019
entrez:
16
8
2019
pubmed:
16
8
2019
medline:
3
3
2020
Statut:
epublish
Résumé
Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization and allergic diseases were associated with altered vascular biomarkers in Norwegian adolescents. Distensibility coefficient of the common carotid arteries, carotid intima-media thickness and atopic sensitization (serum total and specific IgEs) were assessed in 95 Norwegian adolescents, who participated in the RHINESSA generation study. Symptoms of allergic disease were assessed by an interviewer-led questionnaire. Atopic sensitization was found in 33 (34.7%) of the adolescents. Symptomatic allergic disease was found in 11 (33.3%) of those with atopic sensitization. Distensibility coefficient of the common carotid arteries appeared to be lower in participants with atopic sensitization than in those without (46.99±8.07*10-3/kPa versus 51.50±11.46*10-3/kPa; p>0.05), while carotid intima-media thickness did not differ between these groups (0.50±0.04mm versus 0.50±0.04mm; p>0.05). Crude, as well as age- and sex-adjusted multiple regression, revealed no significant association, neither of atopic sensitization nor of allergic disease, with distensibility coefficient of the common carotid arteries and carotid intima-media thickness. Our results do not support the assumption of an adverse impact of atopic sensitization and/or allergic disease on distensibility coefficient of the common carotid arteries and carotid intima-media thickness in Norwegian adolescents. Further research is necessary to study whether the clinical severity of allergic diseases might be more important than the status of allergic disease or atopic sensitization.
Sections du résumé
BACKGROUND
Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization and allergic diseases were associated with altered vascular biomarkers in Norwegian adolescents.
METHODS
Distensibility coefficient of the common carotid arteries, carotid intima-media thickness and atopic sensitization (serum total and specific IgEs) were assessed in 95 Norwegian adolescents, who participated in the RHINESSA generation study. Symptoms of allergic disease were assessed by an interviewer-led questionnaire.
RESULTS
Atopic sensitization was found in 33 (34.7%) of the adolescents. Symptomatic allergic disease was found in 11 (33.3%) of those with atopic sensitization. Distensibility coefficient of the common carotid arteries appeared to be lower in participants with atopic sensitization than in those without (46.99±8.07*10-3/kPa versus 51.50±11.46*10-3/kPa; p>0.05), while carotid intima-media thickness did not differ between these groups (0.50±0.04mm versus 0.50±0.04mm; p>0.05). Crude, as well as age- and sex-adjusted multiple regression, revealed no significant association, neither of atopic sensitization nor of allergic disease, with distensibility coefficient of the common carotid arteries and carotid intima-media thickness.
CONCLUSIONS
Our results do not support the assumption of an adverse impact of atopic sensitization and/or allergic disease on distensibility coefficient of the common carotid arteries and carotid intima-media thickness in Norwegian adolescents. Further research is necessary to study whether the clinical severity of allergic diseases might be more important than the status of allergic disease or atopic sensitization.
Identifiants
pubmed: 31415591
doi: 10.1371/journal.pone.0220198
pii: PONE-D-19-06701
pmc: PMC6695156
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0220198Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):E134-42
pubmed: 11116078
Eur Respir J. 2000 Nov;16(5):866-70
pubmed: 11153585
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13043-8
pubmed: 12244213
Am J Cardiol. 2002 Nov 21;90(10C):3L-7L
pubmed: 12459418
Eur Heart J. 2003 Mar;24(6):515-21
pubmed: 12643884
J Hypertens Suppl. 1992 Jul;10(5):S37-41
pubmed: 1403232
J Allergy Clin Immunol. 2004 Jan;113(1 Suppl):S8-14
pubmed: 14694344
N Engl J Med. 2004 Jan 1;350(1):29-37
pubmed: 14702425
Annu Rev Immunol. 2004;22:361-403
pubmed: 15032582
Acta Paediatr. 2005 Jun;94(6):643-51
pubmed: 16188762
Arch Intern Med. 2005 Nov 28;165(21):2521-6
pubmed: 16314550
J Lipid Res. 2007 Apr;48(4):768-81
pubmed: 17261875
J Clin Endocrinol Metab. 2007 Jun;92(6):2053-7
pubmed: 17374703
Immunol Rev. 2007 Jun;217:105-22
pubmed: 17498055
Acta Paediatr. 2007 Jul;96(7):1030-5
pubmed: 17498194
Autoimmun Rev. 2008 Jul;7(7):558-66
pubmed: 18625445
Pediatr Allergy Immunol. 2009 Jun;20(4):370-6
pubmed: 18801009
Antioxid Redox Signal. 2010 Jul 1;13(1):39-75
pubmed: 19888833
Circ Cardiovasc Qual Outcomes. 2010 Mar;3(2):196-203
pubmed: 20197510
Eur J Pediatr. 2011 Jun;170(6):719-29
pubmed: 20978785
Stat Med. 2011 Feb 20;30(4):377-99
pubmed: 21225900
Asian Pac J Allergy Immunol. 2010 Dec;28(4):256-61
pubmed: 21337909
Pol Arch Med Wewn. 2011 Apr;121(4):109-14
pubmed: 21532532
J Clin Invest. 2011 Sep;121(9):3564-77
pubmed: 21821913
Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2975-81
pubmed: 21940950
Thromb Haemost. 2011 Nov;106(5):858-67
pubmed: 22012133
Int J Cardiol. 2013 May 25;165(3):528-32
pubmed: 22014414
Hypertension. 2012 Jan;59(1):54-61
pubmed: 22068867
Pediatrics. 2012 Jan;129(1):193-7
pubmed: 22201146
Ultrasound Med Biol. 2012 Aug;38(8):1440-50
pubmed: 22749339
Cerebrovasc Dis. 2012;34(4):290-6
pubmed: 23128470
Ann Hum Biol. 2013 May;40(3):220-7
pubmed: 23414181
Hypertension. 2013 Sep;62(3):550-6
pubmed: 23817494
PLoS One. 2013 Sep 09;8(9):e74301
pubmed: 24040224
Int J Cardiol. 2014 Jan 1;170(3):278-85
pubmed: 24315352
Eur J Prev Cardiol. 2015 Nov;22(11):1480-7
pubmed: 25301873
Atherosclerosis. 2015 Feb;238(2):380-7
pubmed: 25555270
N Engl J Med. 1989 Apr 6;320(14):915-24
pubmed: 2648148
Atherosclerosis. 2015 Dec;243(2):609-15
pubmed: 26545015
PLoS One. 2016 Sep 29;11(9):e0163844
pubmed: 27685325
Eur J Prev Cardiol. 2017 Nov;24(17):1809-1818
pubmed: 28696134
Arterioscler Thromb Vasc Biol. 1995 Jun;15(6):811-9
pubmed: 7773738
N Engl J Med. 1996 Jan 18;334(3):150-4
pubmed: 8531969
N Engl J Med. 1997 Apr 3;336(14):973-9
pubmed: 9077376