Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies.
antibiotics
cancer
meta-analysis
risk factor
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 Aug 2019
14 Aug 2019
Historique:
received:
31
07
2019
revised:
10
08
2019
accepted:
11
08
2019
entrez:
17
8
2019
pubmed:
17
8
2019
medline:
17
8
2019
Statut:
epublish
Résumé
The association between antibiotic use and risk of cancer development is unclear, and clinical trials are lacking. We performed a systematic review and meta-analysis of observational studies to assess the association between antibiotic use and risk of cancer. PubMed, the Cochrane Library and EMBASE were searched from inception to 24 February 2019 for studies reporting antibiotic use and subsequent risk of cancer. We included observational studies of adult subjects with previous exposure to antibiotics and available information on incident cancer diagnoses. For each of the eligible studies, data were collected by three reviewers. Risk of cancer was pooled to provide an adjusted odds ratio (OR) with a 95% confidence interval (CI). The primary outcome was the risk of developing cancer in ever versus non-antibiotic users. Cancer risk's association with antibiotic intake was evaluated among 7,947,270 participants (
Identifiants
pubmed: 31416208
pii: cancers11081174
doi: 10.3390/cancers11081174
pmc: PMC6721461
pii:
doi:
Types de publication
Journal Article
Langues
eng
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