Microtubule-Associated Proteins: Structuring the Cytoskeleton.
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
21
05
2019
revised:
11
07
2019
accepted:
12
07
2019
pubmed:
17
8
2019
medline:
8
7
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more complex picture of these proteins as organizers of the microtubule cytoskeleton that have a large variety of functions. MAPs enable microtubules to participate in a plethora of cellular processes such as the assembly of mitotic and meiotic spindles, neuronal development, and the formation of the ciliary axoneme. Although some subgroups of MAPs have been exhaustively characterized, a strikingly large number of MAPs remain barely characterized other than their interactions with microtubules. We provide a comprehensive view on the currently known MAPs in mammals. We discuss their molecular mechanisms and functions, as well as their physiological role and links to pathologies.
Identifiants
pubmed: 31416684
pii: S0962-8924(19)30120-5
doi: 10.1016/j.tcb.2019.07.004
pii:
doi:
Substances chimiques
Microtubule-Associated Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
804-819Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.