New insights into the role of iron in inflammation and atherosclerosis.
Atherosclerosis
Hepcidin-ferroportin axis
Intraplaque haemorrhage
Iron metabolism
Macrophages
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
15
07
2019
revised:
05
08
2019
accepted:
06
08
2019
pubmed:
17
8
2019
medline:
6
2
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
Iron is fundamental for life-essential processes. However, it can also cause oxidative damage, which is thought to trigger numerous pathologies, including cardiovascular diseases. The role of iron in the pathogenesis of atherosclerosis is still not completely understood. Macrophages are both key players in the handling of iron throughout the body and in the onset, progression and destabilization of atherosclerotic plaques. Iron itself might impact atherosclerosis through its effects on macrophages. However, while targeting iron metabolism within macrophages may have some beneficial effects on preventing atherosclerotic plaque progression there may also be negative consequences. Thus, the prevailing view of iron being capable of accelerating the progression of coronary disease through lipid peroxidation may not fully take into account the multi-faceted role of iron in pathogenesis of atherosclerosis. In this review, we will summarize the current understanding of iron metabolism in the context of the complex interplay between iron, inflammation, and atherosclerosis.
Identifiants
pubmed: 31416722
pii: S2352-3964(19)30530-4
doi: 10.1016/j.ebiom.2019.08.014
pmc: PMC6796517
pii:
doi:
Substances chimiques
Hepcidins
0
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
598-606Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
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