Paediatric chronic myeloid leukaemia: Is it really a different disease?


Journal

The Indian journal of medical research
ISSN: 0971-5916
Titre abrégé: Indian J Med Res
Pays: India
ID NLM: 0374701

Informations de publication

Date de publication:
05 2019
Historique:
entrez: 17 8 2019
pubmed: 17 8 2019
medline: 19 2 2020
Statut: ppublish

Résumé

Paediatric chronic myeloid leukaemia (CML) has biological and clinical differences from adult CML. Management of paediatric CML presents unique challenges in growing children, and there are no specific guidelines for paediatric CML. This review focusses on the clinical characteristics, diagnostic issues and management of paediatric CML. Major studies that provide the basis of managing paediatric CML are summerized here. Studies conducted on adult CML patients were used to guide the management of places where studies were lacking in paediatric CML. Recently, dasatinib and nilotinib have been approved for treatment of paediatric CML, and their role has been discussed in the current management perspective. Allogeneic transplant, fertility and vaccination in paediatric CML, have also been discussed.

Identifiants

pubmed: 31417027
pii: IndianJMedRes_2019_149_5_600_264269
doi: 10.4103/ijmr.IJMR_331_19
pmc: PMC6702689
doi:

Substances chimiques

Antineoplastic Agents 0
Pyrimidines 0
Thiazoles 0
Imatinib Mesylate 8A1O1M485B
nilotinib F41401512X
Dasatinib RBZ1571X5H

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

600-609

Déclaration de conflit d'intérêts

None

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Auteurs

Deepam Pushpam (D)

Department of Medical Oncology, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Sameer Bakhshi (S)

Department of Medical Oncology, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

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