Interplay of protein corona and immune cells controls blood residency of liposomes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
17
01
2019
accepted:
26
07
2019
entrez:
17
8
2019
pubmed:
17
8
2019
medline:
18
12
2019
Statut:
epublish
Résumé
In vivo liposomes, like other types of nanoparticles, acquire a totally new 'biological identity' due to the formation of a biomolecular coating known as the protein corona that depends on and modifies the liposomes' synthetic identity. The liposome-protein corona is a dynamic interface that regulates the interaction of liposomes with the physiological environment. Here we show that the biological identity of liposomes is clearly linked to their sequestration from peripheral blood mononuclear cells (PBMCs) of healthy donors that ultimately leads to removal from the bloodstream. Pre-coating liposomes with an artificial corona made of human plasma proteins drastically reduces capture by circulating leukocytes in whole blood and may be an effective strategy to enable prolonged circulation in vivo. We conclude with a critical assessment of the key concepts of liposome technology that need to be reviewed for its definitive clinical translation.
Identifiants
pubmed: 31417080
doi: 10.1038/s41467-019-11642-7
pii: 10.1038/s41467-019-11642-7
pmc: PMC6695391
doi:
Substances chimiques
Blood Proteins
0
Liposomes
0
Protein Corona
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3686Commentaires et corrections
Type : ErratumIn
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