Long-term cardiovascular disorders in the STOX1 mouse model of preeclampsia.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
22
02
2019
accepted:
31
07
2019
entrez:
17
8
2019
pubmed:
17
8
2019
medline:
22
10
2020
Statut:
epublish
Résumé
Adverse long-term cardiovascular (CV) consequences of PE are well established in women. However, the mechanism responsible for that risk remains unknown. Here, we mated wild-type female mice of the FVB/N strain to STOX1A-overexpressing mice to mimic severe PE and investigated the long-term consequences on the maternal cardiovascular system. Ultrasonography parameters were analyzed in mice before pregnancy and at 3 and 6 months post-pregnancy. At 6 months post-pregnancy, cardiac stress test induced by dobutamine injection revealed an abnormal ultrasonography Doppler profile in mice with previous PE. Eight months post-pregnancy, the heart, endothelial cells (ECs) and plasma of females were analyzed and compared to controls. The heart of mice with PE showed left-ventricular hypertrophy associated with altered histology (fibrosis). Transcriptomic analysis revealed the deregulation of 1149 genes in purified ECs and of 165 genes in the hearts, many being involved in heart hypertrophy. In ECs, the upregulated genes were associated with inflammation and cellular stress. Systems biology analysis identified interleukin 6 (IL-6) as a hub gene connecting these pathways. Plasma profiling of 33 cytokines showed that, 8 of them (Cxcl13, Cxcl16, Cxcl11, IL-16, IL-10, IL-2, IL-4 and Ccl1) allowed to discriminate mice with previous PE from controls. Thus, PE triggers female long-term CV consequences on the STOX1 mouse model.
Identifiants
pubmed: 31417152
doi: 10.1038/s41598-019-48427-3
pii: 10.1038/s41598-019-48427-3
pmc: PMC6695383
doi:
Substances chimiques
Carrier Proteins
0
Cytokines
0
STOX1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11918Références
J Hum Hypertens. 2005 Feb;19(2):149-54
pubmed: 15361891
Thyroid. 2008 Jun;18(6):625-30
pubmed: 18578611
J Mol Cell Cardiol. 2005 Dec;39(6):992-5
pubmed: 16242150
Am J Obstet Gynecol. 2013 May;208(5):388.e1-388.e10
pubmed: 23497796
Hypertension. 2015 Apr;65(4):863-70
pubmed: 25712723
FASEB J. 2005 Jul;19(9):1158-60
pubmed: 15833768
Cardiovasc Res. 2011 Dec 1;92(3):466-75
pubmed: 21933910
Int J Biochem Cell Biol. 2001 Jan;33(1):33-44
pubmed: 11167130
Am J Pathol. 2004 Aug;165(2):601-8
pubmed: 15277233
Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H189-93
pubmed: 19915174
Front Immunol. 2017 Apr 21;8:405
pubmed: 28484449
Matrix Biol. 2015 Apr;43:15-26
pubmed: 25661523
J Hypertens. 2010 Jul;28(7):1349-55
pubmed: 20467325
ScientificWorldJournal. 2011 Jul 28;11:1509-24
pubmed: 21805020
Microvasc Res. 2008 Jan;75(1):1-8
pubmed: 17553534
Heart Fail Rev. 2014 Mar;19(2):227-36
pubmed: 23589353
Nephrol Dial Transplant. 1999 May;14(5):1129-32
pubmed: 10344350
BMJ. 2001 Nov 24;323(7323):1213-7
pubmed: 11719411
Sci Rep. 2016 Jan 13;6:19196
pubmed: 26758611
J Am Heart Assoc. 2018 Mar 19;7(6):
pubmed: 29555642
Am J Reprod Immunol. 2016 Mar;75(3):402-10
pubmed: 26685057
Cardiol Rev. 2014 May-Jun;22(3):147-51
pubmed: 24618929
Am J Physiol Regul Integr Comp Physiol. 2018 Sep 1;315(3):R521-R528
pubmed: 29897824
Int J Cardiovasc Imaging. 2015 Oct;31(7):1361-8
pubmed: 26077816
FASEB J. 2014 Jan;28(1):256-64
pubmed: 24029533
Sci Rep. 2019 Jun 12;9(1):8561
pubmed: 31189914
Heart. 2017 Feb;103(3):235-243
pubmed: 27530133
Can J Cardiol. 2019 Jan;35(1):68-76
pubmed: 30595185
Life Sci. 2016 May 1;152:244-8
pubmed: 26596563
Iran J Kidney Dis. 2011 Sep;5(5):324-7
pubmed: 21876309
Circ Res. 2005 Jun 10;96(11):1208-16
pubmed: 15905459
Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):622-8
pubmed: 18162611
Nat Genet. 2005 May;37(5):514-9
pubmed: 15806103
Heart. 2015 Oct;101(19):1584-90
pubmed: 26243788
Biol Reprod. 2012 Aug 23;87(2):42
pubmed: 22674387
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6
pubmed: 12571362
Mol Cell Biol. 2015 Oct;35(19):3312-23
pubmed: 26195821
Trends Cardiovasc Med. 2019 Nov;29(8):429-437
pubmed: 30553703
Am Heart J. 2008 Nov;156(5):918-30
pubmed: 19061708
Mol Cell Biochem. 2018 Dec;449(1-2):227-236
pubmed: 29802597
PLoS One. 2018 Jun 12;13(6):e0198908
pubmed: 29894501
Cell Death Discov. 2018 Feb 15;4:27
pubmed: 29531824
J Cell Mol Med. 2007 Jul-Aug;11(4):621-43
pubmed: 17760829
Neurosci Biobehav Rev. 2013 Jun;37(5):790-802
pubmed: 23524280
J Hypertens. 2018 Jun;36(6):1399-1406
pubmed: 29465714
Hypertension. 2011 Sep;58(3):489-96
pubmed: 21768525
Cytokine. 2013 Apr;62(1):165-73
pubmed: 23523008
Cardiovasc Res. 2014 Mar 15;101(4):579-86
pubmed: 24532051
Hypertension. 2011 Oct;58(4):716-24
pubmed: 21859968
Hypertension. 2013 Mar;61(3):662-8
pubmed: 23357179
J Hypertens. 2013 Jul;31(7):1414-23; discussion 1423
pubmed: 23552130
Jpn Heart J. 2004 Mar;45(2):183-93
pubmed: 15090695
Circ Res. 2004 Mar 5;94(4):534-41
pubmed: 14699015
Ann Anat. 2017 Nov;214:43-52
pubmed: 28865773
J Immunol. 1998 Sep 1;161(5):2501-8
pubmed: 9725249
Hum Mol Genet. 2010 Jul 1;19(13):2658-67
pubmed: 20400461
Antioxid Redox Signal. 2014 Aug 20;21(6):819-34
pubmed: 24738702
Hypertension. 2004 Nov;44(5):708-14
pubmed: 15452036
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9199-204
pubmed: 15201433
Nature. 2011 Sep 11;478(7367):103-9
pubmed: 21909115
Pregnancy Hypertens. 2018 Jul;13:14-21
pubmed: 30177042
Circ Heart Fail. 2011 Sep;4(5):621-7
pubmed: 21622850
Lancet. 2010 Aug 21;376(9741):631-44
pubmed: 20598363
JCI Insight. 2018 Apr 19;3(8):
pubmed: 29669946
PLoS One. 2016 Sep 22;11(9):e0162487
pubmed: 27658290
Circ Res. 2007 Aug 3;101(3):313-21
pubmed: 17569887
BJOG. 2003 Nov;110(11):1029-31
pubmed: 14592589