Guidelines for evaluating myocardial cell death.
apoptosis
autophagic cell death
cardiovascular disease
ferroptosis
heart
mitochondrial-mediated necrosis
necroptosis
pyroptosis
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 11 2019
01 11 2019
Historique:
pubmed:
17
8
2019
medline:
9
4
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
Cell death is a fundamental process in cardiac pathologies. Recent studies have revealed multiple forms of cell death, and several of them have been demonstrated to underlie adverse cardiac remodeling and heart failure. With the expansion in the area of myocardial cell death and increasing concerns over rigor and reproducibility, it is important and timely to set a guideline for the best practices of evaluating myocardial cell death. There are six major forms of regulated cell death observed in cardiac pathologies, namely apoptosis, necroptosis, mitochondrial-mediated necrosis, pyroptosis, ferroptosis, and autophagic cell death. In this article, we describe the best methods to identify, measure, and evaluate these modes of myocardial cell death. In addition, we discuss the limitations of currently practiced myocardial cell death mechanisms.
Identifiants
pubmed: 31418596
doi: 10.1152/ajpheart.00259.2019
pmc: PMC6879915
doi:
Substances chimiques
Biomarkers
0
Intracellular Signaling Peptides and Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Webcast
Langues
eng
Sous-ensembles de citation
IM
Pagination
H891-H922Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL113281
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002649
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113134
Pays : United States
Organisme : NHLBI NIH HHS
ID : R56 HL136816
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL116205
Pays : United States
Commentaires et corrections
Type : ErratumIn
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