Cerebellar parcellation in schizophrenia and bipolar disorder.
cerebellum
lithium
parcellation
segmentation
Journal
Acta psychiatrica Scandinavica
ISSN: 1600-0447
Titre abrégé: Acta Psychiatr Scand
Pays: United States
ID NLM: 0370364
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
accepted:
12
08
2019
pubmed:
17
8
2019
medline:
18
9
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
The cerebellum is involved in cognitive processing and emotion control. Cerebellar alterations could explain symptoms of schizophrenia spectrum disorder (SZ) and bipolar disorder (BD). In addition, literature suggests that lithium might influence cerebellar anatomy. Our aim was to study cerebellar anatomy in SZ and BD, and investigate the effect of lithium. Participants from 7 centers worldwide underwent a 3T MRI. We included 182 patients with SZ, 144 patients with BD, and 322 controls. We automatically segmented the cerebellum using the CERES pipeline. All outputs were visually inspected. Patients with SZ showed a smaller global cerebellar gray matter volume compared to controls, with most of the changes located to the cognitive part of the cerebellum (Crus II and lobule VIIb). This decrease was present in the subgroup of patients with recent-onset SZ. We did not find any alterations in the cerebellum in patients with BD. However, patients medicated with lithium had a larger size of the anterior cerebellum, compared to patients not treated with lithium. Our multicenter study supports a distinct pattern of cerebellar alterations in SZ and BD.
Substances chimiques
Antimanic Agents
0
Lithium Compounds
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
468-476Subventions
Organisme : Agence Nationale de la Recherche
ID : ANR-11-IDEX-0004
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-11-INBS-006
Pays : International
Organisme : Agence Nationale de la Recherche
ID : ANR-14-CE35-0035
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB636/C6 and We3638/3-1
Pays : International
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NV16-32696A
Pays : International
Organisme : Ministerstvo Zdravotnictví Ceské Republiky
ID : NV16-32791A
Pays : International
Organisme : NIMH NIH HHS
ID : R01 MH076971
Pays : United States
Organisme : Regione Veneto Italy
ID : 159/03
Pays : International
Organisme : Regione Veneto Italy
ID : DGRV n. 4087
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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