The effect of Cornus mas fruit extract consumption on lipid profile, glycemic indices, and leptin in postmenopausal women- A randomized clinical trial.
Antioxidants
/ pharmacology
Blood Glucose
/ drug effects
Body Mass Index
Body Weight
/ drug effects
Cornus
/ chemistry
Female
Fruit
/ chemistry
Humans
Insulin
/ blood
Insulin Resistance
/ physiology
Leptin
/ blood
Lipid Metabolism
/ drug effects
Lipids
/ blood
Middle Aged
Plant Extracts
/ pharmacology
Postmenopause
/ blood
Cornus
insulin resistance
leptin
lipidemia
menopause
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
03
03
2019
revised:
01
06
2019
accepted:
22
07
2019
pubmed:
17
8
2019
medline:
16
1
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
Menopause, which occurs following a declined ovarian activity and reduced estrogen levels, can lead to long-term changes in lipid and glycemic profiles and increases the risk of cardiovascular disease and osteoporosis. Cornelian cherry (Cornus mas) is rich in phytochemicals and antioxidants, which appears to be useful in reducing the postmenopausal complications. This interventional, double-blinded, randomized clinical trial carried out on 84 menopaused women aged 45-60 years old. They were randomly divided into two groups. The treatment group received three capsules of 300 mg of Cornus mas extract (CME), and control group received three capsules of 300 mg of starch powder per day for 8 weeks. Then, BMI, waist circumference, glycemic indices, lipid profile, serum apoproteinase, apoprotein B100, fibrinogen, and leptin were measured. The dietary intakes were evaluated using 24-hr dietary recall questionnaire. The consumption of CME in comparison with the control group resulted in a significant reduction in weight, body mass index, waist circumference, LDL to HDL ratio, total cholesterol to HDL ratio, and fibrinogen. There was also a significant increase in HDL and ApoA1 levels in the treatment group. Furthermore, there was a significant decrease in BMI, waist circumference, fasting insulin, and insulin resistance index after 8 weeks of using CME. Summing up the results, it can be concluded that CME can have possible effects on decreasing BMI, waist circumference, and improving some aspects of lipid profile and glycemic indices in postmenopausal women.
Substances chimiques
Antioxidants
0
Blood Glucose
0
Insulin
0
Leptin
0
Lipids
0
Plant Extracts
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2979-2988Subventions
Organisme : Iran University of Medical Sciences
ID : 40-6-8-94
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
Abdollahi, B., Mesgari Abbasi, M., Zakeri Milani, P., Sadat Nourdadgar, A., Banan Khojasteh, S. M., & Nejati, V. (2014). Hydro-methanolic extract of cornus MAS L. and blood glucose, lipid profile and hematological parameters of male rats. Iranian Red Crescent Medical Journal, 16(5), e17784. https://doi.org/10.5812/ircmj.17784
AKh, A., Zaichkina, S. I., Ruzieva, R., & Ganassi, E. E. (1993). The protective action of a natural preparation of anthocyan (pelargonidin-3, 5-diglucoside). Radiobiologiia, 33(3), 433-435.
Al-Azzawi, F. (2001). The menopause and its treatment in perspective. Postgraduate Medical Journal, 77(907), 292-304.
Apostolidis, E., Kwon, Y. I., Shetty, K., Apostolidis, E., & Kwon, Y. I. (2006). Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pacific Journal of Clinical Nutrition, 15(3), 433-441.
Asgary, S., Rafieian-Kopaei, M., Adelnia, A., Kazemi, S., & Shamsi, F. (2010). Comparing the effects of lovastatin and cornus MAS fruit on fibrinogen level in hypercholesterolemic rabbits. ARYA atherosclerosis, 6(1), 1.
Ataie-Jafari, A., Hosseini, S., Karimi, F., & Pajouhi, M. (2008). Effects of sour cherry juice on blood glucose and some cardiovascular risk factors improvements in diabetic women: A pilot study. Nutrition & Food Science, 38(4), 355-360. https://doi.org/10.1108/00346650810891414
Azzini, E., Giacometti, J., & Russo, G. L. (2017). Antiobesity effects of anthocyanins in preclinical and clinical studies. Oxidative Medicine and Cellular Longevity, 2017, 1-11. https://doi.org/10.1155/2017/2740364
Basu, A., Betts, N. M., Ortiz, J., Simmons, B., Wu, M., & Lyons, T. J. (2011). Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome. Nutrition Research, 31(3), 190-196. https://doi.org/10.1016/j.nutres.2011.02.003
Basu, A., du, M., Leyva, M. J., Sanchez, K., Betts, N. M., Wu, M., … Lyons, T. J. (2010). Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome-3. The Journal of Nutrition, 140(9), 1582-1587. https://doi.org/10.3945/jn.110.124701
Beyer, T. P., Chen, Y., Porter, R. K., Lu, D., Schmidt, R. J., Mantlo, N. B., … Cao, G. (2008). Peroxisome proliferator-activated receptor α agonists regulate cholesterol ester transfer protein. Lipids, 43(7), 611-618. https://doi.org/10.1007/s11745-008-3187-0
Chamberlain, G., & Bowen-Simpkins, P. (2000). A Practice of Obstetrics and Gynaecology: A Textbook for General Practice and the DRCOG. Edinburgh: Elsevier Health Sciences.
Cherniack, E. P. (2011). Polyphenols: Planting the seeds of treatment for the metabolic syndrome. Nutrition, 27(6), 617-623.
Coates, P. M., Betz, J. M., Blackman, M. R., Betz, J. M., Cragg, G. M., Levine, M. A., … White, J. D. (2010). Encyclopedia of dietary supplements. London: Informa Healthcare.
Deng, S., West, B. J., & Jensen, C. J. (2013). UPLC-TOF-MS characterization and identification of bioactive iridoids in Cornus mas fruit. Journal of Analytical Methods in Chemistry, 2013, 710972.
DeSouza, C. A., Stevenson, E. T., Davy, K. P., Jones, P. P., & Seals, D. R. (1997). Plasma fibrinogen levels in healthy postmenopausal women: physical activity and hormone replacement status. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 52(5), M294-M298.
Du, C., Shi, Y., Ren, Y., Wu, H., Yao, F., Wei, J., … Duan, H. (2015). Anthocyanins inhibit high-glucose-induced cholesterol accumulation and inflammation by activating LXRα pathway in HK-2 cells. Drug Design, Development and Therapy, 9, 5099.
Eftekhari, A.'l., Khosrowpanah, S., & Rajaifard, A. (2014). Effect of blueberry supplements on metabolic syndrome. Monthly Journal of Shahid Sadoughi University of Medical Sciences Yazd April 15, 22(1), 963-973.
Gouédard, C., Barouki, R., & Morel, Y. (2004). Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Molecular and Cellular Biology, 24(12), 5209-5222.
Graf, D., Seifert, S., Jaudszus, A., Bub, A., & Watzl, B. (2013). Anthocyanin-rich juice lowers serum cholesterol, leptin, and resistin and improves plasma fatty acid composition in fischer rats. PLoS ONE, 8(6), e66690. https://doi.org/10.1371/journal.pone.0066690
Gülçin, İ., Beydemir, Ş., Şat, ?. G., & Küfrevioğlu, Ö. İ. (2005). Evaluation of antioxidant activity of cornelian cherry (Cornus mas L.). Acta Alimentaria, 34(2), 193-202. https://doi.org/10.1556/AAlim.34.2005.2.13
Jayaprakasam, B., Olson, L. K., Schutzki, R. E., Tai, M. H., & Nair, M. G. (2006). Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas). Journal of Agricultural and Food Chemistry, 54(1), 243-248. https://doi.org/10.1021/jf0520342
Kian, R., Golian, S., & Mehran, B. (2002). Study of the rate, causes and use of replacement hormone replacement therapy in postmenopausal women referred to gynecologic clinics of selected hospitals of Tehran University of Medical Sciences. Quarterly Journal of Hayat. May 15, 8(2), 53-61.
Koçyi̇ği̇t, M., & Özhatay, N. (2006). Wild plants used as medicinal purpose in Yalova (Northwest Turkey). Turkish Journal of Pharmaceutical Sciences, 3(2), 91-103.
Lee, I., Chan, Y. C., Lin, C. W., Lee, W. J., & Sheu, W. H. H. (2008). Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes. Diabetic Medicine, 25(12), 1473-1477. https://doi.org/10.1111/j.1464-5491.2008.02588.x
Lello, S., Capozzi, A., & Scambia, G. (2015). Osteoporosis and cardiovascular disease: an update. Gynecological Endocrinology, 31(8), 590-594.
Liu, C., Sun, J., Lu, Y., & Bo, Y. (2016). Effects of anthocyanin on serum lipids in dyslipidemia patients: A systematic review and meta-analysis. PLoS ONE, 11(9), e0162089. https://doi.org/10.1371/journal.pone.0162089
Mashavi, M., Hanah, R., Boaz, M., Gavish, D., Matas, Z., Fux, A., & Shargorodsky, M. (2008). Effect of homocysteine-lowering therapy on arterial elasticity and metabolic parameters in metformin-treated diabetic patients. Atherosclerosis, 199(2), 362-367. https://doi.org/10.1016/j.atherosclerosis.2007.11.037
Miroddanzadeh, S. (2010). Effect of Antihyperglycemic and Antihyperlipidemic Effects of Blueberry Extract (Cornus mas) on diabetic rats and its comparison with glibenclamide. Journal of Diabetes and Metabolism of Iran. Sep 15, 9(4), 335-343.
Mulabagal, V., Lang, G. A., DeWitt, D. L., Dalavoy, S. S., & Nair, M. G. (2009). Anthocyanin content, lipid peroxidation and cyclooxygenase enzyme inhibitory activities of sweet and sour cherries. Journal of Agricultural and Food Chemistry, 57(4), 1239-1246. https://doi.org/10.1021/jf8032039
Neto, C. C. (2007). Cranberry and blueberry: Evidence for protective effects against cancer and vascular diseases. Molecular Nutrition & Food Research, 51(6), 652-664.
Pawlowska, A. M., Camangi, F., & Braca, A. (2010). Quali-quantitative analysis of flavonoids of Cornus mas L.(Cornaceae) fruits. Food Chemistry, 119(3), 1257-1261.
Pinto, M.d. S., Ghaedian, R., Shinde, R., & Shetty, K. (2010). Potential of cranberry powder for management of hyperglycemia using in vitro models. Journal of Medicinal Food, 13(5), 1036-1044. https://doi.org/10.1089/jmf.2009.0225
Prior, R. L., E. Wilkes, S., R. Rogers, T., Khanal, R. C., Wu, X., & Howard, L. R. (2010). Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. Journal of Agricultural and Food Chemistry, 58(7), 3970-3976. https://doi.org/10.1021/jf902852d
Rajaeefard, A., Mohammad-Beigi, A., & Mohammad-Salehi, N. (2011). Estimation of natural age of menopause in Iranian women: A meta-analysis study. koomesh Journal, 13(1), 1-7.
Rasoulian, H., Shahryar, H. A., Abbaspour, R., & Lotfi, H. (2012). Effects of dietary inclusion of cornelian cherry (Cornus mas L.) fruit on body weight, insulin level and glycemic status of hamsters. Pakistan journal of biological sciences: PJBS, 15(11), 547-550.
Rosenblat, M., Karry, R., & Aviram, M. (2006). Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: Relevance to diabetes. Atherosclerosis, 187(1), 74.e1-74.e10.
Ruel, G., Pomerleau, S., Couture, P., Lemieux, S., Lamarche, B., & Couillard, C. (2006). Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men. British Journal of Nutrition, 96(2), 357-364. https://doi.org/10.1079/BJN20061814
Saha, K., Rahman, M. M., Paul, A. R., Das, S., Haque, S., Jafrin, W., & Mia, A. R. (2013). Changes in lipid profile of postmenopausal women. Mymensingh medical journal: MMJ, 22(4), 706-711.
Seeram, N. P., Momin, R. A., Nair, M. G., & Bourquin, L. D. (2001). Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries. Phytomedicine, 8(5), 362-369. https://doi.org/10.1078/0944-7113-00053
Seeram, N. P., Schutzki, R., Chandra, A., & Nair, M. G. (2002). Characterization, quantification, and bioactivities of anthocyanins in Cornus species. Journal of Agricultural and Food Chemistry, 50(9), 2519-2523. https://doi.org/10.1021/jf0115903
Seymour, E., Lewis, S. K., Urcuyo-Llanes, D. E., Tanone, I. I., Kirakosyan, A., Kaufman, P. B., & Bolling, S. F. (2009). Regular tart cherry intake alters abdominal adiposity, adipose gene transcription, and inflammation in obesity-prone rats fed a high fat diet. Journal of Medicinal Food, 12(5), 935-942. https://doi.org/10.1089/jmf.2008.0270
Tavakkoli Darestani A., Kimiagar S., & Valaei N. (2004). The effect of substituting Iranian walnut as a part of pufa in the diet on the serum lipid profile of mildly hypercholesterolemic post- menopausal women. Journal of Mazandaran University of Medical Sciences, 14(44), 21-32.
Teodoro, T., Zhang, L., Alexander, T., Yue, J., Vranic, M., & Volchuk, A. (2008). Oleanolic acid enhances insulin secretion in pancreatic β-cells. FEBS Letters, 582(9), 1375-1380. https://doi.org/10.1016/j.febslet.2008.03.026
Törrönen, R., Sarkkinen, E., Tapola, N., Hautaniemi, E., Kilpi, K., & Niskanen, L. (2010). Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. British Journal of Nutrition, 103(8), 1094-1097. https://doi.org/10.1017/S0007114509992868
Wu, T., Tang, Q., Gao, Z., Yu, Z., Song, H., Zheng, X., & Chen, W. (2013). Blueberry and mulberry juice prevent obesity development in C57BL/6 mice. PLoS ONE, 8(10), e77585. https://doi.org/10.1371/journal.pone.0077585
Yamahara, J., Mibu, H., Sawada, T., Fujimura, H., Takino, S., Yoshikawa, M., & Kitagawa, I. (1981). Biologically active principles of crude drugs. Antidiabetic principles of corni fructus in experimental diabetes induced by streptozotocin (author's transl). Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan, 101(1), 86-90.
Zhang, W., Hong, D., Zhou, Y., Zhang, Y., Shen, Q., Li, J. Y., … Li, J. (2006). Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake. Biochimica et Biophysica Acta (BBA) - General Subjects, 1760(10), 1505-1512. https://doi.org/10.1016/j.bbagen.2006.05.009