Maternal Overfeeding during Lactation Impairs the Metabolic Response to Fed/Fasting Changing Conditions in the Postweaning Offspring.
breastfeeding
metabolic flexibility
metabolic programming
obesity
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
10
05
2019
revised:
05
07
2019
pubmed:
17
8
2019
medline:
23
6
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
The metabolic response to fed/fasting changing conditions at early age in rats with different predisposition to obesity-related alterations due to maternal conditions during the perinatal period is studied. Offspring of dams made obese by a cafeteria diet and moved to a normal-fat diet 1 month before gestation (O-PCaf, with an apparently normal phenotype in adulthood), and offspring of cafeteria diet-fed dams during lactation (O-CAF, with a thin-outside-fat inside phenotype), together with the offspring of control dams (O-C), are studied at early age. Fasting is associated with downregulation of lipogenesis-related genes in liver and rpWAT, and upregulation of genes related to lipolysis and fatty acid uptake in rpWAT in O-C animals. The response to fed/fasting conditions is impaired in O-CAF, but not in O-PCaf animals. The fasting-induced increase in the expression of Prkaa1 in liver and rpWAT, and the corresponding increase of hepatic AMPKα1 protein levels of O-C animals are attenuated in O-CAF rats, while no alterations are found in O-PCaf animals versus controls. Maternal intake of a cafeteria diet during lactation causes early alterations in the offspring, impairing their metabolic flexibility in response to fed/fasting changing conditions, which may contribute to hindering energy homeostasis maintenance.
Identifiants
pubmed: 31419033
doi: 10.1002/mnfr.201900504
doi:
Substances chimiques
Prkaa2 protein, rat
EC 2.7.11.1
AMP-Activated Protein Kinases
EC 2.7.11.31
Adenylate Kinase
EC 2.7.4.3
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1900504Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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