Urgent Time to Allogeneic Hematopoietic Cell Transplantation: A National Survey of Transplant Physicians and Unrelated Donor Search Coordinators Facilitated by the Histocompatibility Advisory Group to the National Marrow Donor Program.
Allogeneic donors
Allogeneic hematopoietic cell transplantation
Donor selection
National Marrow Donor Program
Urgent time to transplant
Journal
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Titre abrégé: Biol Blood Marrow Transplant
Pays: United States
ID NLM: 9600628
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
08
05
2019
revised:
07
08
2019
accepted:
07
08
2019
pubmed:
17
8
2019
medline:
9
9
2020
entrez:
17
8
2019
Statut:
ppublish
Résumé
To characterize donor search and selection practices, the National Marrow Donor Program (NMDP) Histocompatibility Advisory Group developed a survey of allogeneic hematopoietic cell transplant (HCT) physicians and search coordinators. The objectives were to describe search practices, understand practices surrounding urgent time to HCT, and characterize strategies used when identifying a matched unrelated donor is unlikely. Participants included US physician members of the American Society for Transplantation and Cellular Therapy and donor search coordinators within the NMDP network. The web-based survey was conducted from February to May 2018. Three hundred seventeen of 858 physicians (37%) and 225 of 327 coordinators (69%) responded, of which 263 and 194, respectively, were eligible and included in the analysis. Most centers, 142 (95%), were represented; 108 (72%) had at least 1 physician and 128 (85%) had at least 1 coordinator respondent. Most (68% physicians, 61% coordinators) indicated donor selection decisions were made by individual physicians. Urgent time to HCT was most commonly (90% and 87% of physicians and coordinators, respectively) defined as HCT within 4 to 6 weeks of search initiation. Higher HCT urgency was associated with a higher disease risk index. For urgent cases with low probability of an 8/8 matched unrelated donor , 75% and 80% of physicians and coordinators endorsed a short (1 to 2 weeks) unrelated donor search before proceeding to an alternative donor source. NMDP-provided solutions to expedite donor identification were strongly endorsed. This survey clarified current donor selection practices in the United States and defined urgent time to HCT. These data provide insight to NMDP on potential solutions to support the path to transplant, such as highlighting futile searches and providing alternative donor options at the time of search initiation.
Identifiants
pubmed: 31419569
pii: S1083-8791(19)30516-6
doi: 10.1016/j.bbmt.2019.08.002
pmc: PMC7307219
mid: NIHMS1550139
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2501-2506Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : U24 CA076518
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
Références
Biol Blood Marrow Transplant. 2018 May;24(5):1057-1062
pubmed: 29287807
Biol Blood Marrow Transplant. 2010 Feb;16(2):147-56
pubmed: 20142045
Bone Marrow Transplant. 2013 Mar;48(3):346-50
pubmed: 22863723
Biol Blood Marrow Transplant. 2010 Aug;16(8):1070-5
pubmed: 20036337
Bone Marrow Transplant. 2005 Apr;35(7):645-52
pubmed: 15723086
Biol Blood Marrow Transplant. 2016 Nov;22(11):2038-2046
pubmed: 27496216
N Engl J Med. 2014 Jul 24;371(4):339-48
pubmed: 25054717
Bone Marrow Transplant. 2016 Nov;51(11):1476-1481
pubmed: 27272451
Blood. 2014 Jun 5;123(23):3664-71
pubmed: 24744269