REM sleep muscle activity in idiopathic REM sleep behavior disorder predicts phenoconversion.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
17 09 2019
17 09 2019
Historique:
received:
30
11
2018
accepted:
24
04
2019
pubmed:
20
8
2019
medline:
31
1
2020
entrez:
18
8
2019
Statut:
ppublish
Résumé
To determine whether REM sleep without atonia (RSWA) during polysomnography (PSG) predicts phenoconversion in patients with idiopathic REM sleep behavior disorder (iRBD), a prodromal feature of a neurodegenerative disease. We analyzed RSWA in 60 patients with iRBD, including manual phasic, tonic, and any muscle activity in the submentalis and anterior tibialis muscles and the automated REM atonia index in the submentals. We identified patients who developed parkinsonism or mild cognitive impairment (MCI) during at least 3 years of follow-up after PSG. Kaplan-Meier analysis was performed and receiver operator curves were calculated to determine RSWA cutoffs predicting faster phenoconversion. Twenty-six (43%) patients developed parkinsonism (n = 17) or MCI (n = 9). Phenoconverters were older at iRBD diagnosis ( Patients with iRBD with higher amounts of polysomnographic RSWA had a greater risk of developing Parkinson disease or MCI. Patients with older age and higher RSWA amounts had more rapid phenoconversion than younger patients with RBD. Our study suggests that RSWA is a potential biomarker for risk stratification of iRBD phenoconversion that could facilitate prognostication for patients with iRBD. This study provides Class II evidence that for patients with iRBD, increased RSWA correlates with increased risk for developing parkinsonism or MCI.
Identifiants
pubmed: 31420463
pii: WNL.0000000000008127
doi: 10.1212/WNL.0000000000008127
pmc: PMC6808528
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1171-e1179Subventions
Organisme : NIA NIH HHS
ID : P50 AG016574
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024150
Pays : United States
Informations de copyright
© 2019 American Academy of Neurology.
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