Structural basis for delta cell paracrine regulation in pancreatic islets.

Animals Blood Glucose / metabolism Humans Insulin-Like Growth Factor I / metabolism Insulin-Secreting Cells / cytology Intravital Microscopy Islets of Langerhans / cytology Mice Mice, Transgenic Microscopy, Electron Optical Imaging Optogenetics Paracrine Communication Prediabetic State / metabolism Pseudopodia / metabolism Somatostatin-Secreting Cells / cytology Vascular Endothelial Growth Factor A / metabolism

Journal

Nature communications

ISSN: 2041-1723

Titre abrégé: Nat Commun

Pays: England

ID NLM: 101528555

Informations de publication

Date de publication:
16 08 2019

Historique:

received: 19 09 2018

accepted: 19 07 2019

entrez: 18 8 2019

pubmed: 20 8 2019

medline: 18 12 2019

Statut: epublish

Résumé

Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta cell and alpha cell secretory activity, however the structural basis underlying this regulation has yet to be determined. Most delta cells are elongated and have a well-defined cell soma and a filopodia-like structure. Using in vivo optogenetics and high-speed Ca

Identifiants

DOI: 10.1038/s41467-019-11517-x PMID: 31420552 PMC: PMC6697679

pubmed: 31420552

doi: 10.1038/s41467-019-11517-x

pii: 10.1038/s41467-019-11517-x

pmc: PMC6697679

doi:

Substances chimiques

Blood Glucose 0

Vascular Endothelial Growth Factor A 0

Insulin-Like Growth Factor I 67763-96-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

3700

Subventions

Organisme : NIGMS NIH HHS

ID : P41 GM103412

Pays : United States

Commentaires et corrections

Type : ErratumIn

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