Current status of urinary diagnostic biomarkers for colorectal cancer.
Biomarker
Colorectal cancer
Diagnosis
Urine
Journal
Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
11
07
2019
revised:
13
08
2019
accepted:
13
08
2019
pubmed:
20
8
2019
medline:
20
2
2020
entrez:
18
8
2019
Statut:
ppublish
Résumé
Fecal occult blood test (FOBT) and flexible sigmoidoscopy are the currently using screening methods for colorectal cancer (CRC). However, these methods still have problems of high false positive rates in FOBT and increased invasiveness and cost associated with endoscopy. The development of non-invasive biomarkers is thus important for the diagnosis of CRC. Urine is one of the most commonly used samples for mass screening owing to its non-invasive and simple process of collection; however, the discovery of urinary diagnostic biomarkers for malignancies is still challenging and developing. Since urine contains abundant substances reflecting systemic body condition, urinary biomarker might contribute to detect CRC in a completely non-invasive manner. In this review, we describe the current utility of urinary diagnostic biomarkers for CRC.
Identifiants
pubmed: 31421118
pii: S0009-8981(19)31999-0
doi: 10.1016/j.cca.2019.08.011
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-83Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.