Molecular aspects of delta opioid receptors.

Animals Binding Sites Cell Membrane / metabolism Conserved Sequence Crystallization Gene Expression Regulation Humans Models, Molecular Molecular Structure Phosphotransferases / metabolism Receptors, Opioid, delta / chemistry Signal Transduction / physiology Sodium / metabolism
Delta opioid receptor Desensitization Expression Regulation Signaling Sorting Structure Trafficking

Journal

Vitamins and hormones
ISSN: 0083-6729
Titre abrégé: Vitam Horm
Pays: United States
ID NLM: 0413601

Informations de publication

Date de publication:
2019
Historique:
entrez: 19 8 2019
pubmed: 20 8 2019
medline: 27 3 2020
Statut: ppublish

Résumé

The delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects and functions. Indeed, as opposed to most membrane receptors, DOP is poorly addressed to the plasma membrane. In this chapter, we first review the molecular and cellular mechanisms regulating the expression and the cellular trafficking/sorting of DOP. We then summarize the structural insights of this receptor through the analysis of the existing crystal structures, with a particular focus on the role of the sodium binding site. Finally, we review the current signaling mechanisms mediating receptor function and desensitization.

Identifiants

DOI: 10.1016/bs.vh.2019.06.001 PMID: 31421707
pubmed: 31421707
pii: S0083-6729(19)30047-0
doi: 10.1016/bs.vh.2019.06.001
pii:
doi:

Substances chimiques

Receptors, Opioid, delta 0
Sodium 9NEZ333N27
Phosphotransferases EC 2.7.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

49-90

Subventions

Organisme : CIHR
ID : MOP-136871
Pays : Canada
Organisme : CIHR
ID : PJT-162103
Pays : Canada
Organisme : CIHR
ID : MOP-142219
Pays : Canada
Organisme : CIHR
ID : MOP-324876
Pays : Canada
Organisme : CIHR
ID : MOP-311997
Pays : Canada

Informations de copyright

© 2019 Elsevier Inc. All rights reserved.

Auteurs

Louis Gendron (L)

Department of Pharmacology-Physiology, Université de Sherbrooke, Centre de Recherche du CHUS, Sherbrooke, QC, Canada; Quebec Pain Research Network, Sherbrooke, QC, Canada. Electronic address: louis.gendron@usherbrooke.ca.

Karim Nagi (K)

College of Medicine, Member of QU Health, Qatar University, Doha, Qatar.

Manel Zeghal (M)

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.

Patrick M Giguère (PM)

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada; Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada.

Graciela Pineyro (G)

CHU Sainte-Justine research center, Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; Quebec Pain Research Network, Sherbrooke, QC, Canada.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Séquence conservée › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes chimiques › Cristallisation › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur delta › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Molecular aspects of delta opioid receptors.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Molecular aspects of delta opioid receptors.