Outcomes of Optimised Implantation Technique with Bioresorbable scaffolds: A Pooled Analysis of ABSORB-IV and COMPARE-ABSORB Trials.
Absorb
BVS
DES
PCI
Journal
Cardiovascular revascularization medicine : including molecular interventions
ISSN: 1878-0938
Titre abrégé: Cardiovasc Revasc Med
Pays: United States
ID NLM: 101238551
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
17
04
2019
revised:
17
06
2019
accepted:
16
07
2019
pubmed:
20
8
2019
medline:
27
10
2020
entrez:
19
8
2019
Statut:
ppublish
Résumé
Randomised trials have demonstrated higher midterm rates of adverse events and device thrombosis with Absorb-BVS compared to contemporary drug-eluting-stents (DES). BVS failure was ascribed to the implantation technique and consequently two large randomised trials evaluated the clinical impact of an optimised scaffold-implant-procedure. However, pooling together data from ABSORB-IV and those of the COMPARE-ABSORB, the scaffold was still associated with a statistically significant increased risk of target-vessel myocardial-infarction (OR 1.5; 95% CI 1.04-2.17; P = 0.03) and thrombotic events (OR 2.85; 95% CI 1.33-6.11; P = 0.007) at 1-year. Such kind of results could be in part attributed to a lower radial force and the higher acute recoil of the BVS as observed in previous studies. Besides a painstaking implantation technique, future generations of bioresorbable stents should incorporate an excellent mechanical propriety in order to compete with the current-generation DES.
Identifiants
pubmed: 31422012
pii: S1553-8389(19)30430-0
doi: 10.1016/j.carrev.2019.07.018
pii:
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
559-561Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.